Results 51 to 60 of about 2,351 (123)

A Pilot Survey of Indian Stakeholders: Parents, Doctors, and Grown-Up Patients of Disorders of Sexual Differentiation on Management Decisions and Associated Gender Dysphoria

Journal of Indian Association of Pediatric Surgeons
Background and Aims: Of late, there are many legal representations from select quarters to halt all medical interventions in children with differences of sex development (DSD).
Simmi K. Ratan, Sujoy Neogi, Md Fahim Ahmad, Kanishka Das, Vijaya Raman, Pradnya S. Bendre, Arka Banerjee, Shilpa Sharma, Himanshu Acharya, Vikesh Agrawal, Ramesh Babu   +10 more
doaj   +1 more source

A Phase 1, Open‐Label, Randomized Study to Investigate the Pharmacokinetics and Safety of Multiple Doses of Intranasal Naloxone in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
ABSTRACT This was a Phase 1, open label, randomized, crossover study to evaluate the safety and pharmacokinetics of multiple doses of intranasal naloxone (NCT05377255). Twenty‐four healthy participants were enrolled at a single site in the US to one of two sequences.
David Cassie, Bob Warnock, Faisal Akhtar, Duncan McCloskey, David Wyatt   +4 more
wiley   +1 more source

Associations among sleep quality, cognitive decline, and Alzheimer's disease pathology in older adults: A longitudinal study

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION This study aimed to investigate whether sleep quality predicts cognitive/functional decline, and whether Alzheimer's disease (AD) pathology modifies these relationships. METHODS The Pittsburgh Sleep Quality Index was administered to 326 older adults (113 cognitively normal, 192 mild cognitive impairment, 21 dementia; mean age = 66.
Layaly Shihadeh, Mónica Rosselli, Joshua Conniff, Breton Asken, Alicia Goytizolo, Warren Barker, Emily F. Matusz, Angel Collie, Stephen A. Coombes, Melissa Armstrong, Idaly Velez‐Uribe, Malek Adjouadi, Glenn E. Smith, Ranjan Duara, Steven D. DeKosky, David A. Loewenstein   +15 more
wiley   +1 more source

Factors Associated With Alcohol Intake in Patients With Newly Diagnosed Breast Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
Alcohol intake, a modifiable risk factor for breast cancer, is more common prior to a breast cancer diagnosis for patients who are younger, White, financially secure, exercising, and smoking. These findings highlight opportunities for targeted prevention and alcohol‐reduction interventions in breast cancer care.
Sanjna Rajput, Robert A. Vierkant, Nicole L. Larson, Daniela L. Stan, Dawn M. Mussallem, Stacy D. D'Andre, Fergus J. Couch, Janet E. Olson, Ciara C. O'Sullivan, Kathryn J. Ruddy   +9 more
wiley   +1 more source

Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes

BMC Genomics, 2009
Background Gender appears to be determined by independent programs controlled by the sex-chromosomes and by androgen-dependent programming during embryonic development.
Appari Mahesh, Cario Gunnar, Richter-Unruh Annette, Demeter Janos, Werner Ralf, Bebermeier Jan-Hendrik, Holterhus Paul-Martin, Siebert Reiner, Riepe Felix, Brooks James D, Hiort Olaf   +10 more
doaj   +1 more source

Stage IIIC Bilateral Dysgerminoma in a 16‐Year‐Old Phenotypic Female With 46,XY Complete Gonadal Dysgenesis and Primary Amenorrhea: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Dysgerminoma, the most common malignant ovarian germ cell tumor, has a significantly increased incidence in individuals with 46,XY complete gonadal dysgenesis (Swyer syndrome). However, primary amenorrhea is the hallmark presentation of Swyer syndrome in adolescence.
Mahshid Vasef, Noushin Afshar Moghaddam, Masoomeh Raoufi, Maryam Iranipour, Samar Moghadami   +4 more
wiley   +1 more source

46,XX Differences of Sex Development outside congenital adrenal hyperplasia: pathogenesis, clinical aspects, puberty, sex hormone replacement therapy and fertility outcomes

Frontiers in Endocrinology
The term ‘differences of sex development’ (DSD) refers to a group of congenital conditions that are associated with atypical development of chromosomal, gonadal, and/or anatomical sex.
Marianna Rita Stancampiano, Silvia Laura Carla Meroni, Carmen Bucolo, Gianni Russo   +3 more
doaj   +1 more source

Should We Consider Sacral Nerve Stimulation as a Treatment for Neurogenic Lower Urinary Tract Dysfunction? ICI‐RS 2025

Neurourology and Urodynamics, Volume 45, Issue 5, Page 945-950, June 2026.
ABSTRACT Aims To explore the boundary of clinical use of sacral nerve stimulation (SNS) in neurogenic lower urinary tract dysfunction (NLUTD), identifying barriers to approval and early‐impact research questions. Methods This review is derived from a proposal discussion at the International Consultation on Incontinence‐Research Society in Bristol in ...
Marcus J. Drake, Mathijs de Rijk, Stefania Musco, Jalesh Panicker, Michał Późniak, Nikita Bhatt, Brigitte Schurch   +6 more
wiley   +1 more source

Which Patients With Dysfunctional Voiding Respond Well to Sacral Neuromodulation? ICI‐RS 2025

Neurourology and Urodynamics, Volume 45, Issue 5, Page 937-944, June 2026.
ABSTRACT Aims Dysfunctional voiding (DV) is characterised by fluctuating or intermittent urinary flow during voiding in neurologically normal individuals. Given the different definitions used and heterogeneous pathophysiologies, outcomes following sacral neuromodulation/sacral nerve stimulation (SNM/SNS) are variably reported.
Jalesh N. Panicker, Chris Harding, Hashim Hashim, Claire Hentzen, Nikita Bhatt, Arjun Nambiar, Brigitte Schurch, Mathijs de Rijk, Stefania Musco   +8 more
wiley   +1 more source

Desmoplastic Cutaneous Squamous Cell Carcinoma Is an Aggressive and Potentially Fatal Skin Cancer: A Systematic Review

Journal of Cutaneous Pathology, Volume 53, Issue 6, Page 551-561, June 2026.
ABSTRACT The incidence and mortality of cutaneous squamous cell carcinoma (cSCC) are increasing. Desmoplastic cSCC (dcSCC) is an uncommon yet highly aggressive variant which has received relatively little attention in the literature. No systematic reviews of dcSCC are currently available.
Andrew Dettrick, Haris Mohammed, Thomas Hardman, Nicole Buddle, Ryan Livingston, Duncan Lambie, Rebecca Donkin   +6 more
wiley   +1 more source