Results 61 to 70 of about 168,585,035 (181)

Feminizing Therapy in People With Klinefelter Syndrome and Gender Incongruence: Considerations for Treatment Without Testosterone Blockers

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS; 47, XXY) usually involves male sex development and gender identity. Small studies suggest gender incongruence may be more common in KS, but feminizing gender‑affirming hormone therapy in this group has been scarcely reported.
Maaike Kroon, Tamira Klaziene Klooker, Sabine Elisabeth Hannema, Martin Den Heijer   +3 more
wiley   +1 more source

SRY-negative in 46, XX Male Testicular DSD: a case report

Journal of Biomedicine and Translational Research, 2020
Background: The sex determination process requires distinct signaling pathways to generate either testis or ovaries from the same precursor structures, the primordial gonad.
Nurin Aisyiyah Listyasari, Ardy Santosa, Achmad Zulfa Juniarto   +2 more
doaj   +1 more source

The Need for a Global Registry for Charting the Natural History of Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Although Klinefelter Syndrome (KS) represents the most common sex chromosome aneuploidy, several gaps in knowledge persist regarding optimal management of individuals with this condition. Individuals with KS can have a diverse phenotype including endocrine, neurodevelopmental, and cardiovascular manifestations.
Malika Alimussina, Joseph McElvaney, Corinna Grasemann, Jillian Bryce, Lise Aksglaede, Claudia Boettcher, Lexi Breen, Francesco Carlomagno, Sabine Hannema, Andrea M. Isidori, Inas Mazen, Anna Nordenstrom, S. Faisal Ahmed, Angela K. Lucas‐Herald   +13 more
wiley   +1 more source

Challenges in Management of Ovotesticular Differences in Sex Development in Resource-Limited Settings

Case Reports in Endocrinology
Differences in sex development (DSD) are congenital conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical. Ovotesticular DSD is the rarest variant of DSD where both ovarian and testicular tissues co-exist in an ...
Serwah Bonsu Asafo-Agyei, Emmanuel Ameyaw, Boateng Nimako, Michael Amoah   +3 more
doaj   +1 more source

Elevated plasma miR‐210 expression is associated with atypical genitalia in patients with 46,XY differences in sex development

Molecular Genetics & Genomic Medicine, 2022
Background Differences of sex development (DSD) is a term used for conditions in which the chromosomal, gonadal or phenotypical sex is atypical. 46,XY DSD patients frequently present undervirilized external genitalia.
Felipe Martins Elias, Mirian Yumi Nishi, Maria Helena Palma Sircili, Rafael Loch Bastista, Nathalia Lisboa Gomes, Maria Tereza Martins Ferrari, Elaine Maria Frade Costa, Francisco Tibor Denes, Berenice Bilharinho Mendonca, Sorahia Domenice   +9 more
doaj   +1 more source

Privacy and ethical challenges of the Amelogenin sex test in forensic paternity/kinship analysis: Insights from a 13-year case history

Forensic Science International: Synergy, 2023
The Amelogenin sex test included in forensic DNA typing kits has the potential to identify congenital conditions such as differences/disorders of sex development (DSD).
Alessandro Gabriele, Elena Chierto, Sarah Gino, Serena Inturri, Serena Aneli, Carlo Robino   +5 more
doaj   +1 more source

The Moral (Un)Desirability of New Biomedical Technologies as Potential Techno‐Fixes

Bioethics, EarlyView.
ABSTRACT The techno‐fix argument, used to argue against technological interventions that address the consequences of social problems instead of their underlying causes, is increasingly invoked in biomedical discussions. However, especially in biomedicine, the techno‐fix argument remains conceptually underdeveloped.
Lieke van Kempen, Martine C. de Vries, Nienke de Graeff   +2 more
wiley   +1 more source

The potential of deep learning on the discovery of new genes implicated in differences of sex development

Computational and Structural Biotechnology Journal
Despite advances in understanding genetic causes of DSD (differences of sex development), the molecular cause remains unknown for over half of affected individuals.
Isabel von der Decken, Hamid Azimi, Anna Lauber-Biason   +2 more
doaj   +1 more source

Genetic and Phenotypic Correlations Among Growth, Disease Occurrence, and Reproductive Performance From Calf to Heifer in Girolando Dairy Cattle

Journal of Animal Breeding and Genetics, EarlyView.
ABSTRACT The Girolando breed, a cross between Holstein (Bos taurus) and Gir (Bos indicus), is the primary choice for dairy production in Brazilian tropical regions, as it combines high productive potential with adaptation to the tropical environment.
Laura B. da C. Pereira, Viviane A. Ligori, Hinayah R. de Oliveira, Eula R. Carrara, Carolina A. de S. D. Muniz, Edson L. de A. Ribeiro, Lenira E. F. Zadra   +6 more
wiley   +1 more source

Ethical principles and recommendations for the medical management of differences of sex development (DSD)/intersex in children and adolescents [PDF]

European Journal of Pediatrics, 2009
The medical management of differences of sex development (DSD)/intersex in early childhood has been criticized by patients' advocates as well as bioethicists from an ethical point of view. Some call for a moratorium of any feminizing or masculinizing operations before the age of consent except for medical emergencies.
Wiesemann, Claudia, Ude-Koeller, Susanne, Sinnecker, Gernot H. G., Thyen, Ute   +3 more
openaire   +3 more sources