Results 81 to 90 of about 1,832,263 (342)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Immunogold-labelling localization of chlorophyllase-2 at different developmental stages of Pachira macrocarpa leaves

Biologia Plantarum, 2021
Chlorophyllases (Chlases) are housekeeping proteins in plant cells. The dephytylating enzymes can catalyze chlorophyll (Chl) to form chlorophyllide, but the distribution of Chlases in plant cells is still an interesting debate. Previously, we showed that
T.C. LEE, K.H. LIN, M.Y. HUANG, C.-M. YANG   +3 more
doaj   +1 more source

Variation in the intestinal microbiota at different developmental stages of Hynobius maoershanensis

Ecology and Evolution, 2022
AbstractIntestinal microbiota play an important role in the life of amphibians and its composition may vary by developmental stage. In this study, 16S rRNA high‐throughput sequencing was used to profile the intestinal microbiota of Hynobius maoershanensis, which exclusively inhabit the Maoer Mountain swamp at an altitude of approximately 2,000 m.
Bo Yang, Zhenzhen Cui, Meihong Ning, Yu Chen, Zhengjun Wu, Huayuan Huang   +5 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Method for the molecular and quantitative identification of oocytes and their developmental stage in teleost fish gonads

MethodsX
Fish display diverse reproductive strategies and their gametogenesis is influenced by numerous genetic, physiological and environmental factors. The analysis of 5S rRNA expression levels in gonads has been proposed as useful method for the molecular ...
Joyanta Bir, Iratxe Rojo-Bartolomé, Oihane Diaz de Cerio, Maren Ortiz-Zarragoitia, Ibon Cancio   +4 more
doaj   +1 more source

Transcriptome Analysis of Two Different Developmental Stages of Paeonia lactiflora Seeds

International Journal of Genomics, 2017
Paeonia lactiflora is a herbaceous flower in the family Paeoniaceae with both hypocotyl and epicotyl dormant seeds. We used high-throughput transcriptome sequencing on two different developmental stages of P.
Yonglei Ma, Jinqiu Cui, Xiujun Lu, Lijie Zhang, Zhijing Chen, Riwen Fei, Xiaomei Sun   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Complex and dynamic transcriptional changes allow the helminth Fasciola gigantica to adjust to its intermediate snail and definitive mammalian hosts

BMC Genomics, 2019
Background The tropical liver fluke, Fasciola gigantica causes fasciolosis, an important disease of humans and livestock. We characterized dynamic transcriptional changes associated with the development of the parasite in its two hosts, the snail ...
Xiao-Xuan Zhang, Krystyna Cwiklinski, Rui-Si Hu, Wen-Bin Zheng, Zhao-An Sheng, Fu-Kai Zhang, Hany M. Elsheikha, John P. Dalton, Xing-Quan Zhu   +8 more
doaj   +1 more source

Overall expression pattern of tdTomato in GAD65-tdTomato transgenic mice at different developmental stages.

, 2015
In sagittal brain slices, a high reporter expression was observed in the olfactory bulb and striatum as well as in cortex, hippocampus, brainstem and substantia nigra in all investigated developmental stages (A: P1, B: P3, C: P10, D: adult 2.5 months ...
Marit Sicker (755097), Grit Marx (755098), Johannes Hirrlinger (245824), Ulrike Winkler (245785), Stefanie Besser (755096), Volker Eulenburg (755099), Swen Hülsmann (117240)   +6 more
core   +1 more source