Results 91 to 100 of about 13,324 (296)

Essential supremum norm differentiability

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1985
The points of Gateaux and Fréchet differentiability in L∞(μ,X) are obtained, where (Ω,∑,μ) is a finite measure space and X is a real Banach space. An application of these results is given to the space B(L1(μ,ℝ),X) of all bounded linear operators from L1 ...
I. E. Leonard, K. F. Taylor
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

A note on Hadamard differentiability and differentiability in quadratic mean [PDF]

open access: yes
We proof that Hadamard differentiability in addition with usual assumptions on the loss function for M estimates implies differentiability in quadratic mean. Thus both concepts are exchangeable.
Tinkl, Fabian
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

On Fréchet differentiability of multifunctions

open access: yes, 2005
The purpose of our article is to extend the classical notion of Frechet differentiability to multifunctions. To this end we define the notion of affinity for multifunctions and study the basic properties of affine multifunctions.
Gorokhovik, V. V., Zabreiko, P. P.
core   +1 more source

Pointwise differentiability of higher order for sets [PDF]

open access: yes, 2019
The present paper develops two concepts of pointwise differentiability of higher order for arbitrary subsets of Euclidean space defined by comparing their distance functions to those of smooth submanifolds.
Menne, U.
core   +1 more source

Optimal Control Problem with Necessary Optimality Conditions for the Viscous Dullin-Gottwald-Holm Equation

open access: yesAbstract and Applied Analysis, 2014
We study the quadratic cost optimal control problems for the viscous Dullin-Gottwald-Holm equation. The main novelty of this paper is to derive the necessary optimality conditions of optimal controls, corresponding to physically meaningful distributive ...
Jinsoo Hwang
doaj   +1 more source

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