Results 61 to 70 of about 2,681,020 (311)

Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

Molecular Oncology, EarlyView.
We propose an efficient strategy to suppress ALK inhibitor (ALKi) resistance. By analyzing transcriptome data, we identified emetine as a potential inhibitor. We demonstrated that emetine exhibited effectiveness in inhibiting the growth of ALKi‐resistant cells, and further interpreted its impact on the resistant signatures through drug‐induced RNA ...
Sang‐Min Park, Keeok Haam, Haejeong Heo, Doyeong Kim, Min‐Ju Kim, Hyo‐Jung Jung, Seongwon Cha, Mirang Kim, Haeseung Lee   +8 more
wiley   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Replenishing co‐downregulated miR‐100‐5p and miR‐125b‐5p in malignant germ cell tumors causes growth inhibition through cell cycle disruption

Molecular Oncology, EarlyView.
MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso, Shivani Bailey, Luz Alonso‐Crisostomo, Dawn Ward, Christos Panayi, Zachary G. L. Scurlock, Harpreet K. Saini, Stephen P. Smith, James C. Nicholson, Anton J. Enright, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray   +12 more
wiley   +1 more source

On automorphism groups of Toeplitz subshifts

Discrete Analysis, 2017
On automorphism groups of Toeplitz subshifts, Discrete Analysis 2017:11, 19 pp. A discrete dynamical system is a space $X$ with some kind of structure, together with a map $\sigma\colon X\to X$ that preserves the structure.
Sebastian Donoso, Fabien Durand, Alejandro Maass, Samuel Petite   +3 more
doaj   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

A Garden of Eden theorem for Anosov diffeomorphisms on tori

, 2016
Let $f$ be an Anosov diffeomorphism of the $n$-dimensional torus ${\mathbb{T}}^n$ and $\tau$ a continuous self-mapping of ${\mathbb{T}}^n$ commuting with $f$.
Ceccherini-Silberstein, Tullio, Coornaert, Michel   +1 more
core   +1 more source

Compact integral manifolds of differential systems [PDF]

arXiv, 2010
The boundedness tests for the number of compact integral manifolds of autonomous ordinary differential systems, of autonomous total differential systems, of linear systems of partial differential equations, of Pfaff systems of equations, and of systems of exterior differential equations are proved.
arxiv  

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Dynamical Systems Method (DSM) for solving nonlinear operator equations in Banach spaces [PDF]

, 2010
Let $F(u)=h$ be an operator equation in a Banach space $X$, $\|F'(u)-F'(v)\|\leq \omega(\|u-v\|)$, where $\omega\in C([0,\infty))$, $\omega(0)=0$, $\omega(r)>0$ if $r>0$, $\omega(r)$ is strictly growing on $[0,\infty)$. Denote $A(u):=F'(u)$, where $F'(u)$
Ramm, A. G.
core   +7 more sources

Resolution-scale relativistic formulation of non-differentiable mechanics

, 2019
This article motivates and presents the scale relativistic approach to non-differentiability in mechanics and its relation to quantum mechanics. It stems from the scale relativity proposal to extend the principle of relativity to resolution-scale ...
LeBohec, Stephan, Nottale, Laurent, Teh, Mei-Hui   +2 more
core   +2 more sources