Results 131 to 140 of about 12,501,815 (346)

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

A new filled function method based on global search for solving unconstrained optimization problems

AIMS Mathematics
The filled function method is a deterministic algorithm for finding a global minimizer of global optimization problems, and its effectiveness is closely related to the form of the constructed filled function.
Jia Li , Yuelin Gao , Tiantian Chen , Xiaohua Ma   +3 more
doaj   +1 more source

Multiplicative bijections between algebras of differentiable functions [PDF]

Ann. Acad. Sci. Fenn. Math. 32 (2007) 471-480, 2006
We show that any multiplicative bijection between the algebras of differentiable functions, defined on differentiable manifolds of positive dimension, is an algebra isomorphism, given by composition with a unique diffeomorphism.
arxiv  

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Enhancing Spectroscopic Experiment Calibration through Differentiable Programming

Condensed Matter
In this work, we present an innovative calibration technique leveraging differentiable programming to enhance energy resolution and reduce the energy scale systematic uncertainty in X-ray spectroscopic experiments.
Fabrizio Napolitano
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Some Formulas for Legendre Functions Induced by the Poisson Transform

Acta Polytechnica, 2011
Using the Poisson transform, which maps any homogeneous and infinitely differentiable function on a cone into a corresponding function on a hyperboloid, we derive some integral representations of the Legendre functions.
I. A. Shilin, A. I. Nizhnikov
doaj  

A review of differentiable digital signal processing for music and speech synthesis

Frontiers in Signal Processing
The term “differentiable digital signal processing” describes a family of techniques in which loss function gradients are backpropagated through digital signal processors, facilitating their integration into neural networks.
Ben Hayes, Jordie Shier, György Fazekas, Andrew McPherson, Charalampos Saitis   +4 more
doaj   +1 more source

Asymptotic Behavior of Ground State Radial Solutions for -Laplacian Problems

Journal of Mathematics, 2013
Let , we take up the existence, the uniqueness and the asymptotic behavior of a positive continuous solution to the following nonlinear problem in , , , , where , is a positive differentiable function in and is a positive continuous function in such ...
Sonia Ben Othman, Rym Chemmam, Habib Mâagli   +2 more
doaj   +1 more source

UNA EXTENSIÓN DEL MÉTODO SUBGRADIENTE PARA FUNCIONES CUASICONVEXAS

Pesquimat, 2014
In this work, we consider the problem of minimizing a quasiconvex, continue and Hölder function on the set optimal, not necessarily differentiable. We use the normalized direction of the normal con e of the set level of function and employ the stepsize ...
Frank Navarro Rojas, Tomás Alberto Núñez Lay   +1 more
doaj   +1 more source