Results 61 to 70 of about 270,007 (264)
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Higher Weak Derivatives and Reflexive Algebras of Operators
, 2015 Let D be a self-adjoint operator on a Hilbert space H and x a bounded operator on H. We say that x is n-times weakly D-differentiable, if for any pair of vectors a, b from H the function is n-times differentiable.
Christensen, Erik
core
On the Differentiability of Quaternion Functions
Tbilisi Mathematical Journal, 2012 Motivated by the general problem of extending the classical theory of holomorphic functions of a complex variable to the case of quater- nion functions, we give a notion of an H-derivative for functions of one quaternion variable. We show that the elementary quaternion func- tions introduced by Hamilton as well as the quaternion logarithm function ...
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Operator Differentiable Functions
Publications of the Research Institute for Mathematical Sciences, 2000 We study the Banach {}^* -algebra C^1_{\mathrm{op}}(I) of C^1 -functions on the compact interval I such that the corresponding ...
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Support, convergence, and differentiability properties of generalized convex functions [PDF]
, 1953 John W. Green
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Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Limits of differentiable functions [PDF]
Proceedings of the American Mathematical Society, 1996 Suppose that { f n } \{f_n\} is a sequence of differentiable functions defined on [0,1] which converges uniformly to some differentiable function f f , and { f n ′ } \{f’_n\} converges pointwise to
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On the differentiability of functions of bounded variation [PDF]
, 1936 Bohuš Jurek
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