Results 111 to 120 of about 6,869,034 (305)

count-data-thymus-annotated.rds

, 2021
tissue-specific single-cell read count data showing the changes with ...
Robert Palovics (9552968)
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

count-data-brain-annotated.rds

, 2021
tissue-specific single-cell read count data showing the changes with ...
Robert Palovics (9552968)
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Performance of the Sysmex DI-60 for bronchoalveolar lavage cytology

Journal of Laboratory Medicine
Bronchoalveolar lavage (BAL) is a key diagnostic tool for evaluating pulmonary disorders. Manual microscopy is the reference standard for BAL cytology but is time-consuming.
Godelaine Joris, De Vera Mae Jeraldine, Van Laer Christine, Boeckx Nancy   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

UMI-count modeling and differential expression analysis for single-cell RNA sequencing

Genome Biology, 2018
Read counting and unique molecular identifier (UMI) counting are the principal gene expression quantification schemes used in single-cell RNA-sequencing (scRNA-seq) analysis.
Wenan Chen, Yan Li, John Easton, David Finkelstein, Gang Wu, Xiang Chen   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Evaluation of Hematological Parameters in Children with Idiopathic Facial Paralysis: A Case-control Study

Haseki Tıp Bülteni
Aim:Idiopathic peripheral facial paralysis [Bell’s palsy (BP)] is the most common cause of acute, one-sided facial paralysis, whose etiopathogenesis is currently unknown. However, inflammation is considered to play a role in etiopathogenesis.
Hilal Susam Sen, Yeter Duzenli Kar, Selcuk Kuzu, Nilgun Eroglu, Yigit Senol, Dilek Cavusoglu   +5 more
doaj   +1 more source

Total cell quantification in Cerebrospinal Fluid: Can Alinity hq be an effective alternative?

RevSALUS
Introduction: Cell quantification in the cerebrospinal fluid (CSF) is a critical method for the diagnosis of subarachnoid bleeding, neuro-inflammatory and neoplastic pathologies.
 Frederico Bragança, Rui Barreira, Edna Ribeiro   +2 more
doaj   +1 more source