Results 91 to 100 of about 1,497,332 (283)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Closed-Form Solutions for a Nonlinear Partial Differential Equation Arising in the Study of a Fourth Grade Fluid Model

Journal of Applied Mathematics, 2012
The unsteady unidirectional flow of an incompressible fourth grade fluid bounded by a suddenly moved rigid plate is studied. The governing nonlinear higher order partial differential equation for this flow in a semiinfinite domain is modelled ...
Taha Aziz, F. M. Mahomed
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Numerical Investigation of the Steady State of a Driven Thin Film Equation

Journal of Applied Mathematics, 2013
A third-order ordinary differential equation with application in the flow of a thin liquid film is considered. The boundary conditions come from Tanner's problem for the surface tension driven flow of a thin film.
A. J. Hutchinson, C. Harley, E. Momoniat
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Differential Equations in Fréchet Differentials Occurring in Integral Equations [PDF]

Proceedings of the National Academy of Sciences, 1945
Not ...
openaire   +2 more sources

The Exact Bounded Solution to an Initial Boundary Value Problem for 1D Hyperbolic Equation with Interior Degeneracy. I. Separation of Variables

Journal of Optimization, Differential Equations and Their Applications, 2020
Vladimir L. Borsch, Peter I. Kogut
doaj   +1 more source

Algebraic Properties of First Integrals for Scalar Linear Third-Order ODEs of Maximal Symmetry

Abstract and Applied Analysis, 2013
By use of the Lie symmetry group methods we analyze the relationship between the first integrals of the simplest linear third-order ordinary differential equations (ODEs) and their point symmetries. It is well known that there are three classes of linear
K. S. Mahomed, E. Momoniat
doaj   +1 more source

ADDENDUM TO ‘A BOLTZMANN CORRECTION’

Journal of Optimization, Differential Equations and Their Applications, 2019
Some implications concerning an unobservable medium whose micro-motion (rotational motion in Faraday vortex tubes) produces magnetic phenomena after Maxwell, used in a previous article on the origin of Maxwell’s equation for the magnetic induction (JODEA,
Vladimir V. Borsch
doaj   +1 more source