Results 61 to 70 of about 322,012 (264)
International Journal of Mining Science and Technology, 2023 Investigations on the dynamic mechanical properties and failure mechanisms of coal under in-situ stress is essential for the prevention of dynamic disasters in deep coal mines.
Zhanguo Ma +5 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Development of large radii half-wave plates for CMB satellite missions
, 2014 The successful European Space Agency (ESA) Planck mission has mapped the Cosmic Microwave Background (CMB) temperature anisotropy with unprecedented accuracy.
Brown, M. +14 more
core +1 more source
HardwareXThis article details a pressure and flow sensor system device which enables a framework for the research and development of personalized mechanical ventilator support in a closed-loop or semi-closed-loop control system, where the measurements from this ...
Samuel Hastings +7 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Hysteretic behavior of a belt tensioner: modeling and experimental investigation [PDF]
, 2005 In this paper we describe the modeling of the hysteretic behavior of belt tensioners. An initial experimental device is composed only of the tensioner by using forcing frequencies, preloads and deflection amplitudes.
Dufour, Regis +2 more
core +3 more sources
Jixie chuandong, 2006 Tilting device of converter is the most important mechanical equipment on steel-making. A new type multipoint engagement full suspension flexible gearing is introduced. Primal reducer adopts planet differential load balancing mechanism which can make the
张玉忠, 王铁
doaj
Bioengineering, 2021 Hand prostheses partially restore hand appearance and functionalities. In particular, 3D printers have provided great opportunities by simplifying the manufacturing process and reducing costs.
Daniele Esposito +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source