Results 61 to 70 of about 77,990 (266)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
On the solvability of a fourth order operator differential equations
Electronic Journal of Differential Equations, 2007 We establish sufficient conditions for the solvability of a fourth order operator differential equation. These conditions are expressed in terms of operator coefficients.
Ahmed Nouar
doaj
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Selfadjoint Singular Quasi-Differential Operators for First Order
Hittite Journal of Science and Engineering, 2019 I n this work, using the Calkin-Gorbachuk method firstly all selfadjoint extensions of the minimal operator generated by first order linear singular quasi-differential expression in the weighted Hilbert space of vector-functions on right semi-axis have ...
Pembe Ipek Al, Zameddin Ismailov
doaj +1 more source
First Integrals of Differential Operators from SL(2,ℝ) Symmetries
Mathematics, 2020 The construction of first integrals for SL(2,R)-invariant nth-order ordinary differential equations is a non-trivial problem due to the nonsolvability of the underlying symmetry algebra sl(2,R).
Paola Morando +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
IEEE Access, 2020 Ultrasound scanning has become a highly recommended examination in prenatal diagnosis in many countries. The accurate identification of fetal brain ultrasound scans is crucial to accurate head measurement and brain lesion detection, such as the ...
Ruowei Qu +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Electronic Journal of Differential Equations, 2005 The free undamped infinitesimal transverse vibrations of a thin straight beam are modelled by a forth-order differential equation. This paper investigates the families of fourth-order systems which have one spectrum in common, and correspond to four ...
Kazem Ghanbari
doaj