Results 71 to 80 of about 668,078 (284)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Selfadjoint Singular Quasi-Differential Operators for First Order
Hittite Journal of Science and Engineering, 2019 I n this work, using the Calkin-Gorbachuk method firstly all selfadjoint extensions of the minimal operator generated by first order linear singular quasi-differential expression in the weighted Hilbert space of vector-functions on right semi-axis have ...
Pembe Ipek Al, Zameddin Ismailov
doaj +1 more source
First Integrals of Differential Operators from SL(2,ℝ) Symmetries
Mathematics, 2020 The construction of first integrals for SL(2,R)-invariant nth-order ordinary differential equations is a non-trivial problem due to the nonsolvability of the underlying symmetry algebra sl(2,R).
Paola Morando +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On the solvability of a fourth order operator differential equations
Electronic Journal of Differential Equations, 2007 We establish sufficient conditions for the solvability of a fourth order operator differential equation. These conditions are expressed in terms of operator coefficients.
Ahmed Nouar
doaj
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
IEEE Access, 2020 Ultrasound scanning has become a highly recommended examination in prenatal diagnosis in many countries. The accurate identification of fetal brain ultrasound scans is crucial to accurate head measurement and brain lesion detection, such as the ...
Ruowei Qu +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
On New p-Valent Meromorphic Function Involving Certain Differential and Integral Operators
Abstract and Applied Analysis, 2014 We define new subclasses of meromorphic p-valent functions by using certain differential operator. Combining the differential operator and certain integral operator, we introduce a general p-valent meromorphic function.
Aabed Mohammed, Maslina Darus
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source