Results 81 to 90 of about 77,990 (266)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Asymptotic and Spectral Analysis of a Model of the Piezoelectric Energy Harvester with the Timoshenko Beam as a Substructure

Applied Sciences, 2018
Mathematical analysis of the well known model of a piezoelectric energy harvester is presented. The harvester is designed as a cantilever Timoshenko beam with piezoelectric layers attached to its top and bottom faces.
Marianna A. Shubov
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

On Certain Analogues of Noor Integral Operators Associated with Fractional Integrals

Journal of Function Spaces
In this paper, we employ a q-Noor integral operator to perform a q-analogue of certain fractional integral operator defined on an open unit disc. Then, we make use of the Hadamard convolution product to discuss several related results.
Mojtaba Fardi, Ebrahim Amini, Shrideh Al-Omari   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Differential Subordination Defined by New Generalised Derivative Operator for Analytic Functions

International Journal of Mathematics and Mathematical Sciences, 2010
A new generalised derivative operator μλ1,λ2n,m is introduced. This operator generalised many well-known operators studied earlier by many authors. Using the technique of differential subordination, we will study some of the properties of differential ...
Ma'moun Harayzeh Al-Abbadi, Maslina Darus   +1 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The Maximal Regularity of Nonlinear Second-Order Hyperbolic Boundary Differential Equations

Axioms
In this paper, we show the maximal regularity of nonlinear second-order hyperbolic boundary differential equations. We aim to show if the given second-order partial differential operator satisfies the specific ellipticity condition; additionally, if ...
Xingyu Liu
doaj   +1 more source

Operator Calculus of Differential Chains and Differential Forms [PDF]

The Journal of Geometric Analysis, 2013
68 pages, 14 figures. First posted on the arxiv in 2012, published in Springer's First online 05 September 2013 and published in The Journal of Geometric Analysis, January 2015. Since this paper was posted, two unrelated applications have been published: arXiv:1310.0508 and Seguin and Fried, Math. Models Methods Appl. Sci. 24, 1729 (2014).
openaire   +2 more sources