Results 111 to 120 of about 678,844 (309)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Transcriptomic analyses identify key differentially expressed genes and clinical outcomes between triple-negative and non-triple-negative breast cancer

, 2018
Bo Chen,1,* Hailin Tang,2,* Xi Chen,3,* Guochun Zhang,1 Yulei Wang,1 Xiaoming Xie,2 Ning Liao1 1Department of Breast Cancer, Cancer Center, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China; 2Department of Breast ...
Zhang G, Xie X, Chen X, Wang Y, Liao N, Chen B, Tang H   +6 more
core  

Differentially expressed genes per pathway.

, 2022
Differentially expressed genes and associated pathways. (GIF)
Katrin Horn (261615), Ralf Regenthal (9605354), Achim Aigner (21117), Holger Kirsten (425160), Andrej Teren (799698), Markus Scholz (157675), Kolja Nenoff (12441889), Janne Pott (8911550), Michael Rode (2801746), Kerstin Wirkner (3145080), Markus Loeffler (52391), Joachim Thiery (66414)   +11 more
core   +1 more source

The Role of COL22A1 in the Pathophysiology of Hepatocellular Carcinoma: Evidence from Bioinformatics Exploration

Cancer Management and Research, 2022
Hengyu Tian, Yuanyuan Chen, Renjie Zhang, Jialin Liu Department of Hepatobiliary Surgery, Shenzhen Traditional Chinese Medicine Hospital/The fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, 518033, People ...
Tian H, Chen Y, Zhang R, Liu J
doaj  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differentially expressed genes.

, 2015
Number of differentially expressed genes in Sijung (SJ) and Jumli Marshi (JM) after 4 and 24h of chilling stress, respectively. Blue bars indicate up-regulated genes whereas red bars indicate down-regulated genes (BH P≤0.05).
Olof Olsson (189483), Aakash Chawade (189467), Per Sikora (738880), Angelica Lindlöf (496740)   +3 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Comparative transcriptome analysis between two different cadmium-accumulating genotypes of soybean (Glycine max) in response to cadmium stress

BMC Genomic Data
Background Cadmium (Cd) is extremely toxic and non-essential for plants. Different soybean varieties differ greatly in their Cd accumulation ability, but little is known about the underlying molecular mechanisms. Results Here, we performed transcriptomic
Xiaoqing Liu, Hongmei Zhang, Wei Zhang, Qianru Jia, Xin Chen, Huatao Chen   +5 more
doaj   +1 more source

Promoter Methylation-Regulated Differentially Expressed Genes in Breast Cancer

Breast Cancer: Targets and Therapy, 2023
Samar Sindi,1,* Norah Hamdi,1,2,* Sabah Hassan,1,3 Magdah Ganash,1 Mona Alharbi,1 Najla Alburae,1 Sheren Azhari,1 Shadi Alkhayyat,4 Ayman Linjawi,5 Heba Alkhatabi,6,7 Aisha Elaimi,7,8 Ghadeer Alrefaei,9 Nouf Alsubhi,10 Aziza Alrafiah,7 Safiah ...
Sindi S, Hamdi N, Hassan S, Ganash M, Alharbi M, Alburae N, Azhari S, Alkhayyat S, Linjawi A, Alkhatabi H, Elaimi A, Alrefaei G, Alsubhi N, Alrafiah A, Alhazmi S   +14 more
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source