Results 121 to 130 of about 678,844 (309)

Genes differentially expressed in nonagenarians.

, 2013
We found 339 genes that were differentially expressed in female nonagenarians, compared to young female controls, and 248 genes that were differentially expressed in male nonagenarians, compared to young male controls (p FC >1.5). A total of 180 of these
Liina Tserel (420665), Mikko Hurme (240666), Antti Hervonen (239717), Pärt Peterson (275121), Juulia Jylhävä (263169), Matti Nykter (21557), Marja Jylhä (420664), Saara Marttila (420662), Tapio Nevalainen (420663)   +8 more
core   +1 more source

Microarray data mining using Bioconductor packages [PDF]

, 2009
Background - This paper describes the results of a Gene Ontology (GO) term enrichment analysis of chicken microarray data using the Bioconductor packages.
Leunissen JA, van der Poel, J.J., van der Poel J, Martien AM Groenen, Neerincx, P., Groenen, M.A.M., Pieter BT Neerincx, Francesco Ferrari, Nie H, Neerincx PB, Nie, H., Silvio Bicciato, Ferrari, F., Groenen MA, Haisheng Nie, Leunissen, J.A.M., Bicciato, S., FERRARI, Francesco, Poel, J.J., van der, Jan Poel, Jack AM Leunissen, BICCIATO, Silvio   +21 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Identification of Differentially Expressed IGFBP5-Related Genes in Breast Cancer Tumor Tissues Using cDNA Microarray Experiments

, 2015
IGFBP5 is an important regulatory protein in breast cancer progression. We tried to identify differentially expressed genes (DEGs) between breast tumor tissues with IGFBP5 overexpression and their adjacent normal tissues.
AKKİPRİK, MUSTAFA, ÖZER, SIDIKA AYŞE, GÜLLÜ AMURAN, GÖKÇE, KAYA, HANDAN, GÜLLÜOĞLU, MAHMUT BAHADIR   +4 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Network of differentially expressed genes.

, 2014
This network contains interconnections among 20 differentially expressed genes in response to HCV-core protein stimulation. Upregulated genes are indicated in green, and downregulated genes and gene classes in red.
Hugo R. Rosen (222012), Young S. Hahn (362545), Michael Strong (2076), Lucy Golden-Mason (242863), Linling Cheng (404343)   +4 more
core   +1 more source

Identification of potential crucial genes and mechanisms associated with metabolically unhealthy obesity based on the gene expression profile

Frontiers in Genetics
BackgroundObesity is an epidemic and systemic metabolic disease that seriously endangers human health. This study aimed to understand the transcriptomic characteristics of the blood of metabolically unhealthy obesity (MUO) and provide insight into the ...
Qingqing Wang, Silu Wang, Zhanyu Zhuang, Zhanyu Zhuang, Xueting Wu, Xueting Wu, Hongkun Gao, Tianyi Zhang, Tianyi Zhang, Guorong Zou, Guorong Zou, Xing Ge, Xing Ge, Yapeng Liu   +13 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Identification of Differentially Expressed Genes Between Cloned and Zygote-Developing Zebrafish (Danio rerio) Embryos at the Dome Stage Using Suppression Subtractive Hybridization

, 2009
Comparative analyses of differentially expressed genes between somatic cell nuclear transfer (SCNT) embryos and zygote-developing (ZD) embryos are important for understanding the molecular mechanism underlying the reprogramming processes. Herein, we used
Luo, Daji, Chen, Shangping, Zhu, ZY, Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China, Hu, Wei, Zhu, Zuoyan, Sun, Yonghua, Xiao, Yi   +6 more
core   +1 more source