Results 141 to 150 of about 678,844 (309)

Detection of common pathogenesis of rheumatoid arthritis and atherosclerosis via microarray data analysis

Heliyon
Despite extensive research reveal rheumatoid arthritis (RA) is related to atherosclerosis (AS), common pathogenesis between these two diseases still needs to be explored. In current study, we explored the common pathogenesis between rheumatoid arthritis (
Fan Xu, Linfeng Xie, Jian He, Qiuyu Huang, Yanming Shen, Liangwan Chen, Xiaohong Zeng   +6 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Clustering of differentially expressed genes.

, 2019
Clustering of differentially expressed genes.
Shaohua Wang (1447912), Xiaojun Liu (58952), Zhiyong Xia (1622602), Guoqiang Xie (308706), Bin Tang (56654), Shigui Wang (522258)   +5 more
core   +1 more source

Integrative bioinformatics analysis identifies ubiquitin-related genes and their regulatory networks in hepatoblastoma

Discover Oncology
Background Hepatoblastoma (HB), the most common pediatric liver malignancy, poses significant challenges in early diagnosis and treatment. To identify ubiquitin-related genes (UbRGs) and signaling pathways involved in HB progression, we analyzed HB ...
Jiahui Wu, Shuxia Xu
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Detection of differentially expressed genes.

, 2012
The plot (left) shows the log fold change (y-axis) vs. log relative concentration (x-axis) for the cercariae – 3-hour schistosomula comparison. A total of 1,518 genes are differentially expressed between these two life cycles stages (adjusted p ...
Claire Davidson (188710), Thomas D. Otto (188722), Anna V. Protasio (188679), Sophia J. Parker-Manuel (188723), R. Alan Wilson (91815), Martin Hunt (188686), Jacquelline McQuillan (188720), Sarah Nichol (188683), Gary P. Dillon (91813), Nishadi De Silva (188693), Tim J. C. Anderson (188702), Richard C. Clark (188706), Christine Lloyd (188718), Michael A. Quail (166793), Matthew Berriman (5353), Adhemar Zerlotini (188726), Philip T. LoVerde (188717), Giles S. Velarde (188697), Martin A. Aslett (188689), Anne Babbage (188681), Nancy E. Holroyd (188714), David W. Dunne (115501), Guilherme Oliveira (128322), Isheng J. Tsai (147744)   +23 more
core   +1 more source

Bioinformatics analysis of the association between obesity and gastric cancer

Frontiers in Genetics
BackgroundObesity and gastric cancer (GC) are prevalent diseases worldwide. In particular, the number of patients with obesity is increasing annually, while the incidence and mortality rates of GC are ranked high. Consequently, these conditions seriously
Xiaole Ma, Miao Cui, Yuntong Guo
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source