Results 151 to 160 of about 678,844 (309)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

KEGG pathway analysis of differentially expressed genes.

, 2016
Summary of the number of differentially expressed genes in each KEGG pathway. The percentage of the differentially expressed genes account for the predicted genes are shown above the bars.
Chenghao Guo (3228930), Yi Zhang (9093), Yao Wang (102387), Wei Ding (690), Xihui Shen (229806), Meiru Si (675416), Can Chen (675404), Junfeng Pan (507285), Xiaobing Yang (642808)   +8 more
core   +1 more source

Corrigendum: Identification of key endometrial microRNAs and their target genes associated with pathogenesis of recurrent implantation failure by integrated bioinformatics analysis

Frontiers in Genetics, 2022
Jin Shang, Yan-Fei Cheng, Yan-Fei Cheng, Min Li, Hui Wang, Jin-Ning Zhang, Xin-Meng Guo, Dan-dan Cao, Yuan-Qing Yao, Yuan-Qing Yao   +9 more
doaj   +1 more source

Unraveling shared molecular signatures and potential therapeutic targets linking psoriasis and acute myocardial infarction

Scientific Reports
Psoriasis, a chronic inflammatory skin disorder, is associated with comorbidities such as acute myocardial infarction (AMI). However, the molecular mechanisms connecting these conditions are unclear.
Zheming Yang, Jiayin Li, Haixu Song, Zhu Mei, Shuli Zhang, Hanlin Wu, Jing liu, Chenghui Yan, Yaling Han   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Applying Differentially Expressed Genes From Rodent Models of Chronic Stress to Research of Stress-Related Disease: An Online Database

, 2014
Objective To systematically collect differentially expressed genes (DEGs) from rodent models of chronic stress (CS) and apply them to research of stress-related disease.
Zhang, Weina, Chang, Suhua, Guo, Liyuan, Du, Yang, Wang, Jing   +4 more
core  

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Differentially expressed genes in the samples.

, 2016
(A) Hierarchical clustering and heat map of differentially expressed genes based on the expression levels (RPKM). Genes in red and blue represent highly and lowly expressed genes, respectively.
Linchun Mao (751338), Zisheng Luo (751336), Jiayin Li (2659045), Zia Ullah Khan (2621278), Li Li (14993), Xiaoya Tao (3168222), Tiejin Ying (751339)   +6 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source