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Differentially Expressed Genes in Endothelial Differentiation
DNA and Cell Biology, 2005By screening differentially expressed genes in mouse embryonic stem (ES) cells by subtractive hybridization, we identified three conserved but uncharacterized genes encoding bromodomain containing 3 (BRD3), protein lysine methyltransferase (PLM), and kelch domain containing 2 (KLHDC2), which were downregulated during endothelial differentiation. An RNA
Hideshi Ishii +3 more
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Adipocyte Differentiation and Gene Expression
The Journal of Nutrition, 2000The major function of adipocytes is to store triacylglycerol in periods of energy excess and to mobilize this energy during times of deprivation. The short-term control of these lipogenic and lipolytic processes is carefully modulated by hormonal signals from the bloodstream, which provide an inventory of the body's metabolic state.
J M, Ntambi, K, Young-Cheul
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Differential expression of genes in retinoblastoma
Clinica Chimica Acta, 2011Retinoblastoma is a pediatric eye tumor that serves as a paradigm for understanding the genetic basis of cancer. Mutations and/or epigenetic alterations inactivating both alleles of the retinoblastoma gene (RB) are associated with retinoblastoma. There are many other genes which express differentially in the preneoplastic retinal cells after RB loss ...
Parul, Saxena, Jasbir, Kaur
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Mesothelial Differentiation as Reflected by Differential Gene Expression
American Journal of Respiratory Cell and Molecular Biology, 2004Abstract Human mesothelial cells obtained from benign effusions retain their proliferative capacity and grow uniformly either with a fibroblastic or epithelioid morphology in vitro. These cultures therefore provide a model for the process of mesothelial differentiation in vivo. To study this differentiation, we isolated differentially
Xiaojuan, Sun +2 more
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2023
This chapter reviews the evidence from molecular biology, cell biology, and somatic cell nuclear cloning that has shown that each cell of the body carries the same nuclear genome. It analyzes differential gene expression from genetically identical nuclei that creates different cell types and occurs at the levels of gene transcription, pre-mRNA ...
Michael J. F. Barresi, Scott F. Gilbert
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This chapter reviews the evidence from molecular biology, cell biology, and somatic cell nuclear cloning that has shown that each cell of the body carries the same nuclear genome. It analyzes differential gene expression from genetically identical nuclei that creates different cell types and occurs at the levels of gene transcription, pre-mRNA ...
Michael J. F. Barresi, Scott F. Gilbert
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From differential gene expression to differential gene function and back
Drug Discovery Today: Technologies, 2004Following the decoding of several plant and animal genomes, the identification of all corresponding transcripts and proteins and understanding how their expression corresponds to physiological and pathological states is the obvious next step. Nucleic acid quantification methods have become increasingly high-throughput and relatively low-cost, and ...
Moitreyee, Chatterjee-Kishore +1 more
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Identifying Differentially Expressed Genes Based on Differentially Expressed Edges
2019Identification of differentially expressed (DE) genes under different experimental conditions is an important task in many microarray-based studies. There are many methods developed to detect DE genes based on either fold-change (FC) strategy or statistical test.
Bolin Chen, Li Gao, Xuequn Shang 0001
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Analysing differential gene expression in cancer
Nature Reviews Cancer, 2003Analysis of messenger RNA and proteins is widely used to compare patterns of gene expression between cells or tissues of different kinds and under different conditions; for example, between normal and cancer cells. The goal of the individuals who are developing these methods has been to enable faster, simpler, more sensitive and systematic analyses ...
Peng, Liang, Arthur B, Pardee
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Differential gene expression in uterine leiomyoma
Journal of Laboratory and Clinical Medicine, 2003Uterine leiomyomas are the most common tumor of the genitourinary system in women and are a major cause of morbidity. The molecular causes of the disease remain unclear. In this study, we examined gene expression in leiomyomas and normal myometrium.
Keith M, Skubitz, Amy P N, Skubitz
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Identification of Differentially Expressed Genes
2014With the jABC it is possible to realize workflows for numerous questions in different fields. The goal of this project was to create a workflow for the identification of differentially expressed genes. This is of special interest in biology, for it gives the opportunity to get a better insight in cellular changes due to exogenous stress, diseases and ...
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