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Mesothelial Differentiation as Reflected by Differential Gene Expression
American Journal of Respiratory Cell and Molecular Biology, 2004Abstract Human mesothelial cells obtained from benign effusions retain their proliferative capacity and grow uniformly either with a fibroblastic or epithelioid morphology in vitro. These cultures therefore provide a model for the process of mesothelial differentiation in vivo. To study this differentiation, we isolated differentially
Xiaojuan, Sun +2 more
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From differential gene expression to differential gene function and back
Drug Discovery Today: Technologies, 2004Following the decoding of several plant and animal genomes, the identification of all corresponding transcripts and proteins and understanding how their expression corresponds to physiological and pathological states is the obvious next step. Nucleic acid quantification methods have become increasingly high-throughput and relatively low-cost, and ...
Moitreyee, Chatterjee-Kishore +1 more
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Identifying Differentially Expressed Genes Based on Differentially Expressed Edges
2019Identification of differentially expressed (DE) genes under different experimental conditions is an important task in many microarray-based studies. There are many methods developed to detect DE genes based on either fold-change (FC) strategy or statistical test.
Bolin Chen, Li Gao, Xuequn Shang 0001
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Analysing differential gene expression in cancer
Nature Reviews Cancer, 2003Analysis of messenger RNA and proteins is widely used to compare patterns of gene expression between cells or tissues of different kinds and under different conditions; for example, between normal and cancer cells. The goal of the individuals who are developing these methods has been to enable faster, simpler, more sensitive and systematic analyses ...
Peng, Liang, Arthur B, Pardee
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Differential gene expression in uterine leiomyoma
Journal of Laboratory and Clinical Medicine, 2003Uterine leiomyomas are the most common tumor of the genitourinary system in women and are a major cause of morbidity. The molecular causes of the disease remain unclear. In this study, we examined gene expression in leiomyomas and normal myometrium.
Keith M, Skubitz, Amy P N, Skubitz
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Identification of Differentially Expressed Genes
2014With the jABC it is possible to realize workflows for numerous questions in different fields. The goal of this project was to create a workflow for the identification of differentially expressed genes. This is of special interest in biology, for it gives the opportunity to get a better insight in cellular changes due to exogenous stress, diseases and ...
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Genes differentially expressed in prostate cancer
BJU International, 2004Because of the heterogeneity of prostate cancer knowledge about the genes involved in prostate carcinogenesis is still very limited. Previously, the use of novel high‐throughput technologies offered the possibility to investigate broad gene expression profiles and thus helped to improve understanding of the molecular basis of prostate disease.
I E, Eder +4 more
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Differential Gene Expression Analysis of Plants
2018Since the next-generation sequencing (NGS) systems were invented and introduced to life science research about a decade ago, the NGS technology has extensively utilized in wide range of genomic, transcriptomic, and evolutionary studies. Compared with other eukaryotic species, the application of NGS technology in plant research reveals some challenges ...
Mark, Arick, Chuan-Yu, Hsu
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Differential Gene Expression in the Auditory System
2005Hearing disorders affect over 10% of the population and this ratio is dramatically increasing with age. Development of appropriate therapeutic approaches requires understanding of the auditory system, which remains largely incomplete. We have identified hearing-specific genes and pathways by mapping over 15000 cochlear expressed sequence tags (ESTs) to
Irene S. Gabashvili +3 more
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A theory of optimal differential gene expression
Biosystems, 2004We investigate a model of optimal regulation, intended to describe large-scale differential gene expression. Relations between the optimal expression patterns and the function of genes are deduced from an optimality principle: the regulators have to maximise a fitness function which they influence directly via a cost term, and indirectly via their ...
Liebermeister, W. +3 more
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