Results 81 to 90 of about 3,459,071 (296)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Complexity of differential and integral equations
Journal of Complexity, 1985 We are interested in the intrinsic difficulty (or complexity) of computing an approximate solution of the linear operator equation Lu = f. Practical examples of such problems include the cases where L is a known partial differential or integral operator. Problems of the form Lu = f are typically solved under the constraint that only partial information
openaire +4 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Differentiated Integration in the European Union
, 2015 The notion of Differentiated Integration is increasingly used in the literature on European integration. Often employed interchangeably with the notion of "flexible integration, diverging views on its nature have led to the emergence of various ...
Leruth, Benjamin
core
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
PESCO’s Microcosm of Differentiated Integration
, 2021 Differentiation, or what some have called the ‘negative starting point’ of integration, has always been the norm in EU defence policy. Political leaders in the European Council are nevertheless mindful of the need to protect their citizens against ...
Blockmans, S.
core +1 more source
, 2020 Published online: 7 September 2020In March 2017, the European Commission issued a White Paper on the Future of Europe, outlining five scenarios for Europe by 2025.
BADULESCU, Claudia
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Economic integration, intensity of competition and R&D incentives [PDF]
A two-country differentiated duopoly model is set out in which economic integration increases firms' incentives to invest in R&D, purely through the effect of increased intensity of competition between firms.
McVicar, Duncan
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source