Results 111 to 120 of about 2,938,585 (308)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The Clinical Value of the I-131 Diagnostic Whole-Body Scan in the Follow-up of Intermediateand High-Risk Patients with Differentiated Thyroid Cancer

Acta Clinica Croatica
The purpose of this study was to analyze the clinical value of the I-131 diagnostic whole-body scan (WBS) during the follow-up of intermediate- and high-risk patients with differentiated thyroid cancer (DTC) with respect to new classification criteria ...
Vlado Wagenhofer, Ivan Mihaljević, Darija Šnajder, Dunja Mudri, Ivana Marić   +4 more
doaj   +1 more source

Nordic pension systems in a European differentiated integration perspective

Pension systems remain a national competence in the EU member states and are undergoing reforms in all European countries. There are some tendencies to integration of the systems, but large differences remain.
Wadensjö, Eskil,, Pintsch, Anne
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

THE COURNOT-BERTRAND PROFIT DIFFERENTIAL : A REVERSAL RESULT IN A DIFFERENTIATED DUOPOLY WITH WAGE BARGAINING [PDF]

This paper compares Cournot and Bertrand equilibria in a downstream differentiated duopoly in which the input price (wage) paid by each downstream firm is the outcome of a strategic bargain with its upstream supplier (labour union).
López, Mónica Correa, Nayor, Robin A.
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

IgG4-related mastitis managed without excision or steroid therapy

Surgical Case Reports
IgG4-related mastitis is an extremely rare IgG4-related sclerosing disease involving the breast that must be differentiated from breast cancer. There is currently no consensus regarding the optimal treatment strategies.
Hirokazu Matsushima, Masayuki Kikuchi, Rika Miyabe, Sota Yamaguchi, Hidenori Kita, Junko Kobayashi, Takashi Ando, Koji Atsuta, Takayoshi Soga, Tsunehiro Shintani   +9 more
doaj   +1 more source

Poorly differentiated thyroid carcinomas: How much poorly differentiated is needed?

, 2011
BACKGROUND: Poorly differentiated (PD) carcinomas of the thyroid are conceptually situated between well-differentiated (papillary or follicular) carcinomas and anaplastic thyroid carcinomas.
Meili, A, Komminoth, P, Komminoth, Paul, Dettmer, M, Moch, H, Paul Komminoth, Hans Steinert, Andreas Meili, Perren, A, Anja Schmitt, Andreas Haldemann, Matthias Dettmer, Dettmer, Matthias, Meili, Andreas, Schmitt, Anja, Schmitt, A, Moch, Holger, Haldemann, Andreas, Aurel Perren, Steinert, Hans, Steinert, H, Perren, Aurel, Haldemann, A, Holger Moch   +23 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source