Results 61 to 70 of about 2,784,026 (307)

Single-molecule imaging of transcription dynamics, RNA localization and fate in human T cells

The EMBO Journal
T cells are critical effector cells counteracting infections and malignancies. To achieve this, they produce pro-inflammatory cytokines, including IFN-γ and TNF.
M Valeria Lattanzio, Nikolina Šoštarić, Nandhini Kanagasabesan, Branka Popović, Antonia Bradarić, Leyma Wardak, Aurélie Guislain, Philipp Savakis, Evelina Tutucci, Monika C Wolkers   +9 more
doaj   +1 more source

Randomness and differentiability

Transactions of the American Mathematical Society, 2015
We characterize some major algorithmic randomness notions via differentiability of effective functions. (1) As the main result we show that a real number z
Vasco Brattka, Joseph S. Miller, André Nies   +2 more
openaire   +2 more sources

auto-differentiation/xad: v1.5.2

<h2>What's Changed</h2> <p>This is a patch release after factoring out the Python bindings, to get the versioning consistent with the xad-py repository.</p> <ul> <li>Updated naming of QuantLib-Risks by @auto ...
Auto Differentiation Dev Team, Xcelerit Team, Jose Melo, xcelerit-squad, dholden3   +4 more
core   +1 more source

Mitochondrial differentiation in kinetoplastid protozoa: a plethora of RNA controls

, 2003
Differentiation of kinetoplastid protozoa during their complex life cycles is accompanied by stepwise changes in mitochondrial functions. Recent studies have begun to reveal multilevel post-transcriptional regulatory mechanisms by which the expression of
Home, Pratik, Adhya, Samit, Bhattacharyya, Suvendra Nath, Basu, Sudarshana, Ghosh, Sanjay, Chatterjee, Saibal, Tripathi, Gayatri, Dhara, Gunjan, Goswami, Srikanta, Mahata, Bidesh   +9 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68

Nature Communications, 2017
Centriole subdistal appendages (SDAs) anchor microtubules in interphase cells, but their composition and assembly mechanisms are unclear. Here the authors show that two new SDA components, CCDC120 and CCDC68, are required for hierarchical SDA assembly ...
Ning Huang, Yuqing Xia, Donghui Zhang, Song Wang, Yitian Bao, Runsheng He, Junlin Teng, Jianguo Chen   +7 more
doaj   +1 more source

auto-differentiation/XAD: v1.5.0

<h2>Added</h2> <ul> <li>Python bindings as <a href="https://pypi.org/project/xad-autodiff/">xad-autodiff</a> in https://github.com/auto-differentiation/XAD/pull/98</li> <li>Added <code>std::is_signed&
Auto Differentiation Dev Team, Xcelerit Team, Jose Melo, xcelerit-squad, dholden3   +4 more
core   +1 more source

Differentiation of human dermal fibroblasts towards endothelial cells

, 2013
The ultimate goal of vascular tissue engineering is the production of functional grafts for clinical use. Difficulties acquiring autologous endothelial cells have motivated the search for alternative cell sources.
Junker, Johan P.E.,, Magnus Grenegård, Rakar, Jonathan,, Junker, Johan,, Jonathan Rakar, Johan P.E. Junker, Gunnar Kratz, Lönnqvist, Susanna,, Karlsson, Lisa K.,, Kratz, Gunnar,, Lisa K. Karlsson, Grenegård, Magnus,, Susanna Lönnqvist   +12 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

Stem Cell Reports, 2017
The blood-brain barrier (BBB) is composed of four cell populations, brain endothelial cells (BECs), pericytes, neurons, and astrocytes. Its role is to precisely regulate the microenvironment of the brain through selective substance crossing.
Kohei Yamamizu, Mio Iwasaki, Hitomi Takakubo, Takumi Sakamoto, Takeshi Ikuno, Mami Miyoshi, Takayuki Kondo, Yoichi Nakao, Masato Nakagawa, Haruhisa Inoue, Jun K. Yamashita   +10 more
doaj   +1 more source