Results 51 to 60 of about 420,207 (298)
, 2023 Estimates of difficulty, performance deviations, reliability and Person/ Item Separation Index for the MET cognitive subscale.
Rafael Guimarães dos Santos (7530908) +3 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Applicability of IOTN Index for Quality Assessment of Orthodontic Treatment Difficulty
Journal of Indian Orthodontic Society, 2023 Background Evaluating the need and assessing the severity of the problem help in concluding the actual need for orthodontic treatment. Many indices had been developed over the years for this purpose, and one of the most used indices is IOTN.
Reem Alwakeel, Deena Barakah
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Indian Journal of TransplantationBackground: Concerns about laparoscopic donor nephrectomies exist. First and foremost, donor safety is a top priority. Second, the kidneys obtained through laparoscopic donor nephrectomy should provide recipients of kidney transplants with excellent ...
Manoj Kumar Dokania +6 more
doaj +1 more source
Modeling the Effect of Target Shape on Movement Performance in a 1D2D Fitts Task
Mathematics, 2022 Fitts’ law is used as a performance measurement metric in human–computer interactions. The original formulation implied that movement time was identical for movements with the same value of the index of difficulty under varied movement amplitude and ...
Chiuhsiang Joe Lin, Chih-Feng Cheng
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Text Difficulty Study: Do machines behave the same as humans regarding text difficulty?
, 2022 Given a task, human learns from easy to hard, whereas the model learns randomly. Undeniably, difficulty insensitive learning leads to great success in NLP, but little attention has been paid to the effect of text difficulty in NLP.
Chen, Bowen +4 more
core +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source