Results 1 to 10 of about 9,592 (218)

Diffuse intrinsic pontine glioma: Poised for progress [PDF]

Frontiers in Oncology, 2012
Diffuse intrinsic pontine gliomas (DIPG) are amongst the most challenging tumors to treat. Surgery is not an option, the effects of radiation therapy are temporary, and no chemotherapeutic agent has demonstrated significant efficacy.
Katherine eWarren
doaj   +6 more sources

Current immunotherapeutic approaches to diffuse intrinsic pontine glioma [PDF]

Frontiers in Genetics
Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumour that occurs in the pons of the brainstem and accounts for over 80% of all brainstem gliomas.
Catherine Lin, Catherine Lin, Catherine Lin, Christian Smith, Christian Smith, James Rutka, James Rutka, James Rutka, James Rutka, James Rutka   +9 more
doaj   +4 more sources

Addressing barriers in diffuse intrinsic pontine glioma: the transformative role of lipid nanoparticulate drug delivery [PDF]

ADMET and DMPK
Background and purpose: The brainstem tumour known as diffuse intrinsic pontine glioma (DIPG), also known as pontine glioma, infiltrative brainstem glioma is uncommon and virtually always affects children.
Zenab Presswala, Sheetal Aacharya, Shreeraj Shah   +2 more
doaj   +2 more sources

The role of brainstem biopsy and targeted therapies in pediatric diffuse midline glioma/diffuse intrinsic pontine glioma [PDF]

Frontiers in Oncology
Pediatric diffuse midline glioma (DMG), including diffuse intrinsic pontine glioma (DIPG), are aggressive brainstem tumors with a dire prognosis, traditionally diagnosed based on MRI characteristics.
Shehryar R. Sheikh, Shehryar R. Sheikh, Violette M. R. Recinos, Eric M. Thompson, Ross Mangum, Mariah Wright-Nadkarni, Bradley Gampel, Neha J. Patel   +7 more
doaj   +2 more sources

Case Report: Low-grade glioma with NF1 loss of function mimicking diffuse intrinsic pontine glioma [PDF]

Frontiers in Surgery
Intrinsic, expansile pontine tumors typically occur in the pediatric population. These tumors characteristically present as diffuse intrinsic pontine glioma (DIPG), which is now considered as diffuse midline glioma (DMG), H3K27-mutated of the pons.
Joshua D. Bernstock, Joshua D. Bernstock, Paramesh V. Karandikar, Jason A. Chen, Jason A. Chen, Jakob Seidlitz, Jakob Seidlitz, Jakob Seidlitz, Gregory K. Friedman, David M. Meredith, Kevin X. Liu, Daphne Haas-Kogan, David A. Reardon, Pier Paolo Peruzzi   +13 more
doaj   +2 more sources

Can Focused Ultrasound Overcome the Failure of Chemotherapy in Treating Pediatric Diffuse Intrinsic Pontine Glioma Due to a Blood–Brain Barrier Obstacle? [PDF]

Pharmaceuticals
Background: The blood–brain barrier (BBB) plays an important role in regulating homeostasis of the central nervous system (CNS), and it is an obstacle for molecules with a molecular weight higher than 500 Da seeking to reach it, making many drugs ...
Silvana Filieri, Morena Miciaccia, Domenico Armenise, Olga Maria Baldelli, Anselma Liturri, Savina Ferorelli, Anna Maria Sardanelli, Maria Grazia Perrone, Antonio Scilimati   +8 more
doaj   +2 more sources

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma [PDF]

The Journal of Clinical Investigation
Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma; DIPG), are uniformly fatal brain tumors that lack effective treatment.
Ryan J. Duchatel, Evangeline R. Jackson, Sarah G. Parackal, Dylan Kiltschewskij, Izac J. Findlay, Abdul Mannan, Dilana E. Staudt, Bryce C. Thomas, Zacary P. Germon, Sandra Laternser, Padraic S. Kearney, M. Fairuz B. Jamaluddin, Alicia M. Douglas, Tyrone Beitaki, Holly P. McEwen, Mika L. Persson, Emily A. Hocke, Vaibhav Jain, Michael Aksu, Elizabeth E. Manning, Heather C. Murray, Nicole M. Verrills, Claire Xin Sun, Paul Daniel, Ricardo E. Vilain, David A. Skerrett-Byrne, Brett Nixon, Susan Hua, Charles E. de Bock, Yolanda Colino-Sanguino, Fatima Valdes-Mora, Maria Tsoli, David S. Ziegler, Murray J. Cairns, Eric H. Raabe, Nicholas A. Vitanza, Esther Hulleman, Timothy N. Phoenix, Carl Koschmann, Frank Alvaro, Christopher V. Dayas, Christopher L. Tinkle, Helen Wheeler, James R. Whittle, David D. Eisenstat, Ron Firestein, Sabine Mueller, Santosh Valvi, Jordan R. Hansford, David M. Ashley, Simon G. Gregory, Lindsay B. Kilburn, Javad Nazarian, Jason E. Cain, Matthew D. Dun   +54 more
doaj   +2 more sources

Diffuse intrinsic pontine gliomas in pediatric patients: management updates

Egyptian Journal of Neurosurgery, 2023
Background This review explores how diffuse intrinsic pontine glioma (DIPG) diagnosis and treatment have evolved and are improving. Main body Authors used various sources from 2000 to present time to compile information on diffuse intrinsic pontine ...
Caroline Davidson, Samuel Woodford, Daisy Valle, Grace Parker, Ann-Marie Derias, Carina Copley, Brandon Lucke-Wold   +6 more
doaj   +1 more source

Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries [PDF]

, 2018
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and ...
Antonelli, Manila, Antonelli, Manila, Bailey, Simon, Bartels, Ute, Baugh, Joshua, Benesch, Martin, Biassoni, Veronica, Bison, Brigitte, Boddaert, Nathalie, Bouffet, Eric, Broniscer, Alberto, Broxson, Emmett, Calmon, Raphael, Castel, David, Chaney, Brooklyn, Chintagumpala, Murali, Colditz, Niclas, Comito, Melanie, Dholaria, Hetal, Doughman, Renee, Drissi, Rachid, Foreman, Nicholas K., Fouladi, Maryam, Fuller, Christine, Gerber, Nicolas U., Giagnacovo, Marzia, Gielen, Gerrit H., Giraud, G´eraldine, Goldman, Stewart, Gottardo, Nicholas, Grill, Jacques, Grotzer, Michael A., Hargrave, Darren, Hassall, Timothy, Hawkins, Cynthia, Hoffman, Lindsey M., Hoffmann, Marion, Hulleman, Esther, Jabado, Nada, Jadrijevic Cvrlje, Filip, Jones, Blaise, Jones, Chris, Jones, David T. W., Kaspers, Gertjan J. L., Khatua, Soumen, Kieran, Mark W., Kramm, Christof M., Lane, Adam, Leach, James, Leary, Sarah, Massimino, Maura, Miles, Lili, Minturn, Jane, Modena, Piergiorgio, Nazarian, Javad, Packer, Roger, Pfaff, Elke, Pfister, Stefan M., Pietsch, Torsten, Puget, Stephanie, Sanchez, Esther, Shih, Chie-Schin, Solanki, Guirish A., Sophie Carret, Anne, Sturm, Dominik, van Vuurden, Dannis G., Vandertop, William P., Varlet, Pascale, Veldhuijzen van Zanten, Sophie E. M., von Bueren, Andr´e O., Warmuth-Metz, Monika, Warren, Katherine E., Yanez Escorza, Nancy, Ziegler, David S.   +73 more
core   +7 more sources

Bridging the age gap: a review of molecularly informed treatments for glioma in adolescents and young adults

Frontiers in Oncology, 2023
Gliomas are the most common primary central nervous system (CNS) tumors and a major cause of cancer-related mortality in children (age <15 years), adolescents and young adults (AYA, ages 15–39 years), and adults (age >39 years). Molecular pathology
Annette Weiser, Annette Weiser, Astrid Sanchez Bergman, Charbel Machaalani, Julie Bennett, Julie Bennett, Patrick Roth, Regina R. Reimann, Javad Nazarian, Javad Nazarian, Ana S. Guerreiro Stucklin, Ana S. Guerreiro Stucklin   +11 more
doaj   +1 more source