Results 101 to 110 of about 9,592 (218)

Peds OncoTalk: A Curriculum to Teach Communication Skills to Pediatric Hematology/Oncology Fellows

Pediatric Blood &Cancer, Volume 72, Issue 11, November 2025.
ABSTRACT Background Peds OncoTalk is a novel curriculum for Pediatric Hematology/Oncology (PHO) fellows to learn key communication skills to deliver cancer care using validated principles. Interpersonal and communication skills are core competencies for Accreditation Council for Graduate Medical Education (ACGME)‐accredited PHO fellowship.
Molly C. Mack, Rene N. Claxton, Robert M. Arnold, Scott H. Maurer   +3 more
wiley   +1 more source

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. [PDF]

, 2020
BackgroundLong non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy.
Akeson, Mark, Birk, Harjus S, Gupta, Nalin, He, Daniel, Hong, Sung Jun, Horlbeck, Max A, Jain, Miten, Koontz, Mark, Lien, Brian V, Lim, Daniel A, Liu, S John, Malatesta, Martina, Monje, Michelle, Olsen, Hugh E, Pedraza, Leslie, Raleigh, David R, Saha, Parna, Seo, Kyounghee, Thombare, Shivani S, Ullian, Erik M, Weissman, Jonathan S   +20 more
core   +1 more source

ODC‐Driven Polyamines Synthesis Sustains the Self‐Renewal of Glioblastoma Stem Cells and Drives Tumor Aggressiveness

Cancer Science, Volume 116, Issue 11, Page 3079-3089, November 2025.
Our findings delineate a novel regulatory network that integrates metabolic and GSCs self‐renewal in GBM. By integrating genetic ODC ablation with multiomic profiling, we redefine polyamine metabolism as a linchpin of GSCs self‐renewal, a dependency exploitable through precision gene editing.
Xue‐Chen Wei, Hao‐Qian Zhang, Guang‐Qin Liu, Chang‐Wei Liu, Ai‐ling Li, Xin Pan, Wei‐Qun Yan, Jia‐Yi Chen   +7 more
wiley   +1 more source

Immune Response Generated With the Administration of Autologous Dendritic Cells Pulsed With an Allogenic Tumoral Cell-Lines Lysate in Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Frontiers in Oncology, 2018
Background and objectiveDiffuse intrinsic pontine glioma (DIPG) is a lethal brainstem tumor in children. Dendritic cells (DCs) have T-cell stimulatory capacity and, therefore, potential antitumor activity for disease control. DCs vaccines have been shown
Daniel Benitez-Ribas, Raquel Cabezón, Georgina Flórez-Grau, Mari Carmen Molero, Patricia Puerta, Antonio Guillen, E. Azucena González-Navarro, Sonia Paco, Sonia Paco, Angel M. Carcaboso, Angel M. Carcaboso, Vicente Santa-Maria Lopez, Vicente Santa-Maria Lopez, Ofelia Cruz, Ofelia Cruz, Carmen de Torres, Carmen de Torres, Noelia Salvador, Noelia Salvador, Manel Juan, Manel Juan, Jaume Mora, Jaume Mora, Andres Morales La Madrid, Andres Morales La Madrid, Andres Morales La Madrid   +25 more
doaj   +1 more source

Convection enhanced delivery of panobinostat (LBH589)-loaded pluronic nano-micelles prolongs survival in the F98 rat glioma model [PDF]

, 2017
BACKGROUND: The pan-histone deacetylase inhibitor panobinostat is a potential therapy for malignant glioma, but it is water insoluble and does not cross the blood–brain barrier when administered systemically. In this article, we describe the in vitro and
Asby, D. J., Barua, N. U., Bienemann, A. S., Butts, C. P., Collins, A. M., Gill, S. S., Haynes, H. R., Killick-Cole, C. L., Singleton, W. G., Wyatt, M. J.   +9 more
core   +2 more sources

Cancer Neuroscience: Decoding Neural Circuitry in Tumor Evolution for Targeted Therapy

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review highlights the pivotal role of the nervous system in cancer progression, emphasizing how neural–tumor interactions—via synaptic signaling, neurotransmitters, and paracrine factors—reshape the tumor microenvironment. It introduces cancer neuroscience as an emerging field and proposes integrating advanced tools such as AI and optogenetics to ...
Mengyu Yuan, Rongjiao Xi, Yong Kang, Ming‐jie Kuang, Xiaoyuan Ji   +4 more
wiley   +1 more source

Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN [PDF]

, 2013
Children and young adults with glioblastoma (GBM) have a median survival rate of only 12 to 15 months, and these GBMs are clinically and biologically distinct from histologically similar cancers in older adults.
Ashworth, A, Bajrami, I, Barretos Cancer Hosp, Bax, D A, Bjerke, L, Burford, A, Carvalho, D, Coimbra, Hargrave, D, Inst Cancer Research, Jones, C, Jury, A, Lord, C J, Mackay, A, McGonnell, I M, Minho, Nandhabalan, M, Popov, S, Reis, R M, Taylor, K R, UCL, Vinci, M, Workman, P   +22 more
core   +2 more sources

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas [PDF]

, 2013
The most common pediatric brain tumors are low-grade gliomas (LGGs). We used whole-genome sequencing to identify multiple new genetic alterations involving BRAF, RAF1, FGFR1, MYB, MYBL1 and genes with histone-related functions, including H3F3A and ATRX ...
A Gajjar, A Korshunov, A Lin, A McPherson, A Peraud, A von Deimling, AJ Sievert, AK Gnekow, B Tang, C Bettegowda, CG Mullighan, CG Mullighan, D Dias-Santagata, D Singh, D Sturm, DA Persons, DN Louis, DN Louis, DT Jones, DT Jones, DT Jones, DW Ellison, DW Parsons, E Bouffet, F Li, G Schindler, G Wu, GT Armstrong, H Cin, H Li, H Ohgaki, H Ohgaki, H Ohgaki, H Yan, I Qaddoumi, IF Pollack, IF Pollack, J Jonkers, J Schwartzentruber, J Wang, J Zhang, J Zhang, J Zhang, JE DeClue, JH Wisoff, JR Downing, KT Flaherty, M Katoh, M Ren, M Wang, MJ Ciesielski, MJ Riemenschneider, ML Bajenaru, MN Edmonson, N Turner, N Turner, ND Dees, PG Fisher, PJ Stephens, PK Duffner, R Endersby, R Listernick, R Listernick, RG Tatevossian, RG Tatevossian, RS Arora, S Pfister, S Yip, T Forshew, T Stokland, TE Merchant, V Rand, W Müller, WM Lin, Y Okamoto   +74 more
core   +1 more source

CDK4/6 and PDGFRA Signaling as Therapeutic Targets in Diffuse Intrinsic Pontine Glioma

Frontiers in Oncology, 2018
Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brain tumors, whereby the standard of care is focal radiation, a treatment that provides temporary relief for most patients.
Christine Hoeman, Chen Shen, Oren J. Becher, Oren J. Becher   +3 more
doaj   +1 more source

Effects of Dual Targeting of Tumor Cells and Stroma in Human Glioblastoma Xenografts with a Tyrosine Kinase Inhibitor against c-MET and VEGFR2 [PDF]

, 2013
Contains fulltext : 118357.pdf (publisher's version ) (Open Access)Anti-angiogenic treatment of glioblastoma with Vascular Endothelial Growth Factor (VEGF)- or VEGF Receptor 2 (VEGFR2) inhibitors normalizes tumor vessels, resulting in a
A Claes, A Claes, A Claes, A Claes, A Narayana, AC Navis, Alan Wright, Anna C. Navis, Annika Bourgonje, Arend Heerschap, B Sennino, C Ponzetto, D Hanahan, D Hof, FM Yakes, HS Friedman, Jeroen A. W. M. van der Laak, JJ Verhoeff, JM Ebos, Joseph Najbauer, K Lamszus, Kiek Verrijp, KM Weidner, KV Lu, M Paez-Ribes, M Snuderl, O Keunen, P Kunkel, P Wesseling, Pieter Wesseling, PY Wen, R Stupp, RK Jain, RK Jain, S Koochekpour, V Caretti, W Leenders, W Liu, Wiljan Hendriks, William P. J. Leenders, WK You, WP Leenders, WS Kamoun, Y Li   +43 more
core   +4 more sources