Results 111 to 120 of about 9,592 (218)

First-in-Human Phase I Study to Evaluate the Brain-Penetrant PI3K/mTOR Inhibitor GDC-0084 in Patients with Progressive or Recurrent High-Grade Glioma. [PDF]

, 2020
PurposeGDC-0084 is an oral, brain-penetrant small-molecule inhibitor of PI3K and mTOR. A first-in-human, phase I study was conducted in patients with recurrent high-grade glioma.Patients and methodsGDC-0084 was administered orally, once daily, to ...
Cloughesy, Timothy F, Coimbra, Alexandre F, Ellingson, Benjamin M, Gerstner, Elizabeth, Lee, Eudocia Q, Lu, Xuyang, Morrissey, Kari M, Mueller, Lars U, Olivero, Alan G, Rodon, Jordi, Wen, Patrick Y, Wilson, Timothy R   +11 more
core  

Biophysical characterization of histone H3.3 K27M point mutation [PDF]

, 2018
K
Boros-Oláh, Beáta, Hetey, Szabolcs, Karányi, Zsolt, Kuik-Rózsa, Tímea, Li, Qiuzhen, Roszik, Jason, Szabó, Zoltán, Szalóki, Nikoletta, Székvölgyi, Lóránt, Tóth, Katalin Ágnes, Vámosi, György   +10 more
core   +1 more source

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

Nature Communications, 2016
Diffuse Intrinsic Pontine Gliomas are diagnosed by sampling a small portion of the tumour. Here, using multiple samples from tumours, the authors analyse the spatial and temporal distribution of driver mutations revealing that H3K27M mutations arise ...
Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael, Rui Li, Tenzin Gayden, Matthew Osmond, Cheng-Ying Ho, Madhuri Kambhampati, Eugene I. Hwang, Damien Faury, Alan Siu, Simon Papillon-Cavanagh, Denise Bechet, Keith L. Ligon, Benjamin Ellezam, Wendy J. Ingram, Caedyn Stinson, Andrew S. Moore, Katherine E. Warren, Jason Karamchandani, Roger J. Packer, Nada Jabado, Jacek Majewski, Javad Nazarian   +23 more
doaj   +1 more source

A case of dural arteriovenous fistula showing high uptake on methionine positron emission tomography and mimicking diffuse intrinsic pontine glioma

Interdisciplinary Neurosurgery
Background: Intracranial dural arteriovenous fistula (dAVF) and gliomas sometimes present with similar imaging findings. Methionine positron emission tomography (MET-PET) is used to diagnose gliomas; however, the findings for dAVF are unknown.
Yuki Sunohara, Kinya Yokoyama, Kai Takayanagi, Kazuki Ishii, Fumiaki Kanamori, Kojiro Ishikawa, Masahiro Nishihori, Takashi Izumi, Ryuta Saito   +8 more
doaj   +1 more source

Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma

Acta Neuropathologica Communications, 2017
Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectable.
Tina Y. Huang, Andrea Piunti, Rishi R. Lulla, Jin Qi, Craig M. Horbinski, Tadanori Tomita, C. David James, Ali Shilatifard, Amanda M. Saratsis   +8 more
doaj   +1 more source

Re-irradiation for progressive Diffuse Intrinsic Pontine Glioma (DIPG): The Spanish experience

EJC Paediatric Oncology
Introduction: Diffuse intrinsic pontine glioma (DIPG) is the most common malignant brainstem tumour in children. Despite advances in understanding its biology, current treatments have shown minimal impact on overall survival in this fatal disease.
Elena Panizo-Morgado, Felisa Vazquez-Gómez, Marta Perez-Somarriba, Miriam Pavon-Mengual, Andrés Morales-La Madrid, Blanca Lopez-Ibor, Palma Solano, Blanca Martinez de las Heras, Marta Cortés-Hernández, Miguel García-Ariza, Roberto Carlos Raynero-Mellado, Marta Martinez-Merino, Ana de Lucio Delgado, María Tallón-García, Carmen Garrido-Colino, Irene Ortiz-Gonzalez, Raquel Portugal, María Baro-Fernández, Carmen Gonzalez San-Segundo, Felipe Calvo, Alvaro Lassaletta   +20 more
doaj   +1 more source

DIVERSet JAG compounds inhibit topoisomerase II and are effective against adult and pediatric high-grade gliomas [PDF]

, 2019
High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients.
Ajaz, Allen, An, Bristow, Broniscer, Broniscer, Cohen, Cohen, Demoulin, Dolecek, Dolgin, Dubey, Felsberg, Feun, Fillmore, Froelich-Ammon, Gewirtz, Hill, Hsieh, Joseph, Korones, Kreis, Lee, Livak, Louis, Mackay, Mehta, Mehta, Merighi, Montenegro, Northcott, Ostrom, Pace, Pollack, Pollack, Pollack, Pollack, Prados, Prados, Shaw, Sirenko, Sonabend, Stupp, Stupp, Sure, Uribe, van den Bent, Waldman, Wijdeven, Wilson, Wu, Yung   +51 more
core   +2 more sources

Metastatic Diffuse Intrinsic Pontine Glioma to the Peritoneal Cavity Via Ventriculoperitoneal Shunt: Case Report and Literature Review

Journal of Neurological Surgery Reports, 2015
Extraneural metastatic disease resulting from a primary central nervous system neoplasm is a rare clinical finding in the pediatric population. We report a case of peritoneal glioblastoma carcinomatosis following placement of a ventriculoperitoneal shunt
Ramon Francisco Barajas Jr., Andrew Phelps, Hallee C. Foster, Jesse Courtier, Benjamin D. Buelow, Nalin Gupta, Theodore Nicolaides, Orit A. Glenn, Anuradha Banerjee   +8 more
doaj   +1 more source

Abstracts

Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley   +1 more source

Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine Glioma

Neurologia medico-chirurgica, 2017
Diffuse intrinsic pontine glioma (DIPG) is a rare but uniformly fatal cancer of the brain, with peak incidence in children of 5-7 years of age. In contrast to most types of human cancer, there has been no significant improvement in treatment outcomes for patients with DIPG.
openaire   +3 more sources