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Diffuse intrinsic pontine glioma: a reassessment
Journal of Neuro-Oncology, 2014Diffuse intrinsic pontine glioma (DIPG) is a disease of childhood whose abysmal prognosis has remained unchanged for over 50 years. Biologic investigation has been stymied by lack of pretreatment tissue, as biopsy has been reserved for atypical cases. Recent advances in surgical and molecular-analytic techniques have increased the safety and potential ...
Nathan J, Robison, Mark W, Kieran
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Diffuse intrinsic pontine gliomas in adults
Neurology India, 2022Background: Brainstem gliomas (BSG) constitutes very small proportion in adults brain tumors with pons as most common location. There is significant paucity in literature for adult diffuse intrinsic pontine gliomas (DIPG). Objective: In this study, we attempt to review the outcomes ...
Sandeep, Kandregula +8 more
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Diffuse Midline Glioma – Diffuse Intrinsic Pontine Glioma
2020Diffuse midline glioma, H3 K27M-mutant, formerly known as diffuse intrinsic pontine glioma (DIPG), is a malignant and infiltrative neoplasm of the pons. DIPG mainly affects the pediatric population and is associated with dismal prognosis, where less than 10% of sufferers survive beyond 2 years from diagnosis.
Mohammad Hassan A. Noureldine +2 more
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Diffuse Intrinsic Pontine Gliomas
2010Brain stem tumors account for 10–15% of all primary childhood CNS tumors. Most of the brain tumors arising in the brain stem are gliomas. With recent advances in neuro-imaging, particularly the advent of magnetic resonance imaging (MRI) and careful correlation of clinical presentation, location, and growth pattern, it has become evident that brain stem
Milind Ronghe +2 more
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Nimotuzumab for pediatric diffuse intrinsic pontine gliomas
Expert Opinion on Biological Therapy, 2010Diffuse intrinsic pontine gliomas (DIPG) have a poor prognosis: the median survival rate is less than one year. Radiotherapy is the only effective treatment affording an overall survival of 6 - 9 months. So far, no improvement has been achieved with the addition of single/poly-chemotherapy regimens. An urgent need is to advance in this field, from both
Massimino, M. +3 more
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Diffuse Intrinsic Pontine Gliomas
2012Diffuse intrinsic pontine gliomas (DIPG) are unique in pediatric neuro-oncology as they are inoperable and rarely being biopsied. They are a relatively clean tumor group to be studied with MR spectroscopy because lesions are always in the same region, generally large and homogeneous, and MR studies are technically not compromised by biopsies or surgery.
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Developing chemotherapy for diffuse pontine intrinsic gliomas (DIPG)
Critical Reviews in Oncology/Hematology, 2017Prognosis of diffuse intrinsic pontine glioma (DIPG) is poor, with a median survival of 10 months after radiation. At present, chemotherapy has failed to show benefits over radiation. Advances in biotechnology have enabled the use of autopsy specimens for genomic analyses and molecular profiling of DIPG, which are quite different from those of ...
Ho-Shin, Gwak, Hyeon Jin, Park
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Palliative Reirradiation for Progressive Diffuse Intrinsic Pontine Glioma
American Journal of Clinical Oncology, 2012Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive tumors and have a poor prognosis. Nearly all patients experience disease progression after definitive treatment, accompanied by severe neurologic deficits and morbidity. Here, we report a series of patients treated with reirradiation for palliation of symptoms.Six patients received ...
Hiral P, Fontanilla +7 more
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An epigenetic therapy for diffuse intrinsic pontine gliomas
Nature Medicine, 2014Diffuse intrinsic pontine glioma is a uniformly lethal malignant tumor of infancy with no effective therapies. A new study reveals that inhibition of JMJD3 has robust antitumor activity in diffuse intrinsic pontine glioma xenografts.
Vijay, Ramaswamy +2 more
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