Results 11 to 20 of about 9,592 (218)

Diffuse Intrinsic Pontine Glioma [PDF]

, 2018
Diffuse intrinsic pontine glioma (DIPG) is a leading cause of brain cancer-related death in children. These aggressive high-grade gliomas cannot be effectively treated and are associated with dismal prognosis.
Gottardo, Nicholas G., Valvi, Santosh
core   +4 more sources

Pre-Clinical Models of Diffuse Intrinsic Pontine Glioma [PDF]

Frontiers in Oncology, 2015
Diffuse Intrinsic Pontine Glioma (DIPG) is a rare and incurable brain tumor that arises in the brainstem of children predominantly between the ages of six and eight.
Oren J Becher, Oren J Becher, Katherine L Misuraca, Francisco J Cordero   +3 more
doaj   +3 more sources

A rare case of a diffuse intrinsic pontine glioma presenting as pathological laughter and apparent hyperactivity in a child

Sri Lanka Journal of Medicine, 2021
Introduction: Diffuse intrinsic pontine gliomas generally present with cranial nerve palsies with cerebellar and pyramidal-tract involvement. The pons has generally not been regarded as a structure that mediates complex affective behaviour.
S. R. Perera, A. S. Rajapakshe
doaj   +1 more source

Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

Nature Communications, 2021
Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in ...
Aaminah Khan, Laura D. Gamble, Dannielle H. Upton, Caitlin Ung, Denise M. T. Yu, Anahid Ehteda, Ruby Pandher, Chelsea Mayoh, Steven Hébert, Nada Jabado, Claudia L. Kleinman, Mark R. Burns, Murray D. Norris, Michelle Haber, Maria Tsoli, David S. Ziegler   +15 more
doaj   +1 more source

Lagophthalmos- A Rare Presenting Sign in a Case of Childhood Pontine Glioma [PDF]

Journal of Clinical and Diagnostic Research, 2020
Brain stem glioma is a rare central nervous system tumour arising from glial cells which occur mostly in children. Diffuse Intrinsic Pontine Gliomas (DIPG) and Focal glioma are the two types of pontine glioma. DIPGs are highly aggressive.
N Gayathri, G Premnath, S Kiruthika, Manoj Vasudevan, Geeta Anusha Loya   +4 more
doaj   +1 more source

MELK Inhibition in Diffuse Intrinsic Pontine Glioma [PDF]

Clinical Cancer Research, 2018
Abstract Purpose: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brain tumor, for which no effective therapeutic options currently exist. We here determined the potential of inhibition of the maternal embryonic leucine zipper kinase (MELK) for the treatment of DIPG.
Michaël H. Meel, Mark C. de Gooijer, Miriam Guillén Navarro, Piotr Waranecki, Marjolein Breur, Levi C.M. Buil, Laurine E. Wedekind, Jos W.R. Twisk, Jan Koster, Rintaro Hashizume, Eric H. Raabe, Angel Montero Carcaboso, Marianna Bugiani, Olaf van Tellingen, Dannis G. van Vuurden, Gertjan J.L. Kaspers, Esther Hulleman   +16 more
openaire   +6 more sources

Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma

Neoplasia: An International Journal for Oncology Research, 2023
Constitutional mismatch repair deficiency (CMMRD) is a cancer predisposition syndrome associated with the development of hypermutant pediatric high-grade glioma, and confers a poor prognosis.
Alyssa Noll, Carrie Myers, Matthew C. Biery, Michael Meechan, Sophie Tahiri, Asmitha Rajendran, Michael E. Berens, Danyelle Paine, Sara Byron, Jiaming Zhang, Conrad Winter, Fiona Pakiam, Sarah E.S. Leary, Bonnie L. Cole, Evangeline R. Jackson, Matthew D. Dun, Jessica B. Foster, Myron K. Evans, Siobhan S. Pattwell, James M. Olson, Nicholas A. Vitanza   +20 more
doaj   +1 more source

Diffuse Intrinsic Pontine Glioma [PDF]

Journal of Child Neurology, 2016
Diffuse intrinsic pontine glioma is a lethal brain cancer that arises in the pons of children. The median survival for children with diffuse intrinsic pontine glioma is less than 1 year from diagnosis, and no improvement in survival has been realized in more than 30 years.
Tammy, Hennika, Oren J, Becher
openaire   +2 more sources

Interdisciplinary care of children with diffuse midline glioma

Neoplasia: An International Journal for Oncology Research, 2023
Diffuse Midline Glioma (DMG) which includes Diffuse Intrinsic Pontine Glioma (DIPG) is an infiltrative tumor of the midline structures of the central nervous system that demonstrates an aggressive pattern of growth and has no known curative treatment. As
Christina Coleman, Katherine Chen, Alex Lu, Elizabeth Seashore, Schuyler Stoller, Taron Davis, Steve Braunstein, Nalin Gupta, Sabine Mueller   +8 more
doaj   +1 more source

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source