Results 31 to 40 of about 9,592 (218)

Intersection of brain development and paediatric diffuse midline gliomas: potential role of microenvironment in tumour growth [PDF]

, 2018
Diffuse intrinsic pontine glioma (DIPG) is a devastating and incurable paediatric brain tumour with a median overall survival of 9 months. Until recently, DIPGs were treated similarly to adult gliomas, but due to the advancement in molecular and imaging ...
Fillmore, Helen, Loveson, Katie
core   +1 more source

Approaches Toward Improving the Prognosis of Pediatric Patients With Glioma: Pursuing Mutant Drug Targets With Emerging Small Molecules [PDF]

, 2014
Gliomas represent approximately 70% of all pediatric brain tumors and most of these are of astrocytic lineage, furthermore, malignant or high-grade astrocytoma account for approximately 20% of pediatric astrocytoma. Treatment options for pediatric glioma
Snape, Timothy J., Warr, Tracy
core   +1 more source

Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion [PDF]

, 2017
Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumours with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via immune-mediated mechanisms ...
Bartolini, Caretti, Cockle, Cockle, Demuth, Dumontet, Etienne-Manneville, Etienne-Manneville, Etienne-Manneville, Fangusaro, Ganguly, Grimes, Hargrave, Harrow, Jones, Kaufman, Khatua, Kirschner, Liao, Louis, Louis, Luo, Lyman, Naghavi, Papanastassiou, Peris, Prestwich, Radtke, Rampling, Reed, Russell, Schroeder, Schulze, Sun, Taylor, Tran, Turnbull, Waterman-Storer, Wollmann   +38 more
core   +6 more sources

From Pediatric to Adult Brain Cancer: Exploring Histone H3 Mutations in Australian Brain Cancer Patients

Biomedicines, 2023
Genetic histone variants have been implicated in cancer development and progression. Mutations affecting the histone 3 (H3) family, H3.1 (encoded by HIST1H3B and HIST1H3C) and H3.3 (encoded by H3F3A), are mainly associated with pediatric brain cancers ...
Benedicte Grebstad Tune, Heena Sareen, Branka Powter, Smadar Kahana-Edwin, Adam Cooper, Eng-Siew Koh, Cheok S. Lee, Joseph W. Po, Geoff McCowage, Mark Dexter, Lucy Cain, Geraldine O’Neill, Victoria Prior, Jonathan Karpelowsky, Maria Tsoli, Lars O. Baumbusch, David Ziegler, Tara L. Roberts, Paul DeSouza, Therese M. Becker, Yafeng Ma   +20 more
doaj   +1 more source

Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma [PDF]

, 2017
Recent exciting work partly through The Cancer Genome Atlas has implicated epigenetic mechanisms including histone modifications in the development of both pediatric and adult high-grade glioma (HGG).
Kurian, Kathreena M, Lowis, Stephen P, Malik, Karim, Singleton, Will G B, Williams, Maria J   +4 more
core   +1 more source

Epigenetic programming of pediatric high-grade glioma: Pushing beyond proof of concept to clinical benefit

Frontiers in Cell and Developmental Biology, 2022
Pediatric high-grade gliomas (pHGG) are a molecularly diverse group of malignancies, each incredibly aggressive and in dire need of treatment advancements.
Andrew Groves, Tabitha M. Cooney
doaj   +1 more source

Development of the SIOPE DIPG network, registry and imaging repository : a collaborative effort to optimize research into a rare and lethal disease [PDF]

, 2017
Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival.
Bailey, S, Barkhof, F, Baugh, J, Biassoni, V, Bison, B, Calmon, R, Cannarozzo, A, Castel, D, Chaney, B, Colditz, N, Cruz, O, Damen-Korbijn, CM, De Jongh, D, De Wolf, R, Deak, L, Emmerik, J, Entz-Werle, N, Fouladi, M, Gandola, L, Garami, M, Gerber, N, Gielen, GH, Gil-da-Costa, MJ, Giraud, G, Grill, J, Grundy, R, Hargrave, DR, Hauser, P, Hayden, T, Hoffmann, M, Holm, S, Hulleman, E, Jacobs, S, Jadrijevic-Cvrlje, F, Janssens, GO, Jones, C, Jones, DT, Kaspers, GJ, Kattamis, A, Kebudi, R, Kitanovski, L, Kivivuori, SM, Kramm, CM, Leblond, P, Lieverst, JA, Lopez-Aguilar, E, Massimino, M, members of the SIOPE DIPG Network, ., Morales La Madrid, A, Noltes, J, Nysom, K, Pears, J, Pentikainen, V, Perek-Polnik, M, Rutkauskiene, G, Sanchez Aliaga, E, Shats, L, Slavc, I, Sturm, D, Sumerauer, D, Thorarinsdottir, HK, Torsvik, IK, Van Dijk, J, Van Gool, S, van Vuurden, DG, Vandertop, WP, Varlet, P, Veldhuijzen van Zanten, SE, von Bueren, AO, Warmuth-Metz, M, Zapata-Tarres, M, Zheludkova, O   +71 more
core   +5 more sources

Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma [PDF]

Cancer Cell, 2017
Diffuse intrinsic pontine glioma (DIPG) is a fatal pediatric cancer with limited therapeutic options. The majority of cases of DIPG exhibit a mutation in histone-3 (H3K27M) that results in oncogenic transcriptional aberrancies. We show here that DIPG is vulnerable to transcriptional disruption using bromodomain inhibition or CDK7 blockade.
Nagaraja, Surya, Vitanza, Nicholas A, Woo, Pamelyn J, Taylor, Kathryn R, Liu, Fang, Zhang, Lei, Li, Meng, Meng, Wei, Ponnuswami, Anitha, Sun, Wenchao, Ma, Jie, Hulleman, Esther, Swigut, Tomek, Wysocka, Joanna, Tang, Yujie, Monje, Michelle   +15 more
openaire   +3 more sources

OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma

Journal of Translational Medicine, 2020
Background Diffuse intrinsic pontine glioma (DIPG) is the most common brainstem cancer in childhood. This rapidly progressing brainstem glioma holds a very dismal prognosis with median survival of less than 1 year.
Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M. Carcaboso, Rheal A. Towner   +8 more
doaj   +1 more source

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Nature Communications, 2019
Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene ...
Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Ángel M. Carcaboso, Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra   +14 more
doaj   +1 more source