Results 41 to 50 of about 9,592 (218)

Brainstem Glioma in Adults [PDF]

, 2016
Brainstem gliomas are not nearly as common in adults as they are in children. They are likely the final common consequence not of a single disease process but of several. They can be difficult to diagnose, and are challenging to treat.
Jethro Hu, Santosh Kesari, Stephen Western   +2 more
core   +2 more sources

Diffuse intrinsic pontine gliomas: New waves [PDF]

Neuro-Oncology, 2012
Brainstem lesions are heterogenous. Although the majority are astrocytomas, adult and pediatric gliomas differ in their molecular genetic aberrations; gliomas located in the brainstem differ biologically from those located supratentorially; and there is tremendous intratumoral variation in histologic type and genetic profile, as shown in the paper by ...
openaire   +2 more sources

Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma [PDF]

Current Neuropharmacology, 2017
Diffuse intrinsic pontine gliomas (DIPGs) are invariably fatal tumors found in the pons of elementary school aged children. These tumors are grade II-IV gliomas, with a median survival of less than 1 year from diagnosis when treated with standard of care (SOC) therapy. Nanotechnology may offer therapeutic options for the treatment of DIPGs.
Bredlau, Amy Lee, Dixit, Suraj, Chen, Chao, Broome, Ann-Marie   +3 more
openaire   +2 more sources

Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma

Acta Neuropathologica Communications, 2018
Diffuse intrinsic pontine glioma (DIPG) is a universally fatal malignancy of the childhood central nervous system, with a median overall survival of 9–11 months.
Grant L. Lin, Surya Nagaraja, Mariella G. Filbin, Mario L. Suvà, Hannes Vogel, Michelle Monje   +5 more
doaj   +1 more source

A phase I/II study of gemcitabine during radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma [PDF]

, 2017
The purpose of this phase I/II, open-label, single-arm trial is to investigate the safety, tolerability, maximum tolerated dose and preliminary efficacy of the potential radiosensitizer gemcitabine, administered concomitantly to radiotherapy, in children
Bakker, D.P. (Dewi P.), El-Khouly, F.E. (Fatma E.), Haasbeek, C.J.A. (Cornelis J.A.), Jansen, M. (Marc), Kaspers, G.J.L. (Gertjan), Sanchez Aliaga, E. (Esther), Vandertop, W.P. (Peter), Veldhuijzen Van Zanten, S.E.M. (Sophie), Vuurden, D.G. (Dannis) van, Wolf, N.I. (Nicole), Zwaan, C.M. (Michel)   +10 more
core   +1 more source

Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy.

PLoS ONE, 2017
Diffuse intrinsic pontine glioma is a very frustrating disease. Since the tumor infiltrates the brain stem, surgical removal is often impossible. For conventional radiotherapy, the dose constraint of the brain stem impedes attempts at further dose ...
Jia-Cheng Lee, Keh-Shih Chuang, Yi-Wei Chen, Fang-Yuh Hsu, Fong-In Chou, Sang-Hue Yen, Yuan-Hung Wu   +6 more
doaj   +1 more source

Developing H3K27M mutant selective radiosensitization strategies in diffuse intrinsic pontine glioma

Neoplasia: An International Journal for Oncology Research, 2023
Diffuse intrinsic pontine glioma (DIPG) is a rare but highly lethal pediatric and adolescent tumor located in the pons of the brainstem. DIPGs harbor unique and specific pathological and molecular alterations, such as the hallmark lysine 27-to-methionine
Leslie A. Parsels, Daniel R Wahl, Carl Koschmann, Meredith A. Morgan, Qiang Zhang   +4 more
doaj   +1 more source

Cell migration in paediatric glioma; characterisation and potential therapeutic targeting [PDF]

, 2015
Background: Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are highly aggressive brain tumours. Their invasive phenotype contributes to their limited therapeutic response, and novel treatments that block brain tumour ...
A Broniscer, A Brüning-Richardson, A M Carcaboso, A Melcher, B Wehrle-Haller, C Jones, CA Grimes, D Del Duca, DN Louis, E Ilett, G Mehta, H Eldar-Finkelman, J Johnson, J Levesley, J Luo, J V Cockle, JG Wakefield, KE Warren, L Meijer, L P Steel, M Vinci, MO Nowicki, OT Fackler, PA Agudelo-Garcia, PB Mitchell, R Hoessel, S E Lawler, S Picton, S Short, SJ Smith, SP Williams, SP Williams, T Demuth, T Siegal, T Sun, VW Van Beusechem, XH Ma   +36 more
core   +2 more sources

Genomic Insights into Diffuse Intrinsic Pontine Glioma [PDF]

Frontiers in Oncology, 2017
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor with a peak incidence in middle childhood and a median survival of less than 1 year. The dismal prognosis associated with DIPG has been exacerbated by the failure of over 250 clinical trials to meaningfully improve survival compared with radiotherapy, the current ...
Lapin, DH, Tsoli, M, Ziegler, DS
openaire   +3 more sources

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. [PDF]

, 2017
We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases.
Adam Resnick, Alan Mackay, Alexei N. Kisljakov, Andrew J. Martin, Andrew S. Moore, André O. von Bueren, Angel Montero Carcaboso, Angela J. Waanders, Anna Burford, Baker, Barrow, Bax, Bender, Bjerke, Bouffet, Buczkowicz, Cai, Cai, Carmen de Torres, Carvalho, Castel, Ceccarelli, Chan, Chris Jones, Christopher Chandler, Cynthia Hawkins, Darach Crimmins, David Castel, David T.W. Jones, Davis, Diana Carvalho, Dmitry M. Konovalov, Dorra H’mida-Ben Brahim, Elisa Izquierdo, Fontebasso, Fontebasso, Funato, Grasso, Hamid Nikbakht, Harry J. Han, Hennika, Henry C. Mandeville, Ho-Keung Ng, Jacques Grill, Janat Fazal-Salom, Jane Cryan, Jane Pears, Jaume Mora, John Caird, Jones, Jones, Jones, João N. Stavale, Kathryn R. Taylor, Khuong-Quang, Korshunov, Korshunov, Kramm, Kun Mu, Leslie R. Bridges, Louis, Lucas T. Bidinotto, Ludmila I. Shats, Lynley Marshall, Lynn Bjerke, Mara Vinci, Marie-Anne Debily, Mariona Sunol, Maryam Fouladi, Matthew Clarke, Meera Nandhabalan, Michael Baudis, Michael Farrell, Michelle Monje, Nada Jabado, Natacha Entz-Werle, Nicolaides, Northcott, Ofelia Cruz, Ostrom, Paugh, Paugh, Paugh, Pichai Raman, Puget, Qin, Richards, Rui M. Reis, Safa Al-Sarraj, Saoussen Trabelsi, Sara Temelso, Saumya Gupta, Schiffman, Schwartzentruber, Sergey Popov, Shlien, Stefan M. Pfister, Stergios Zacharoulis, Sturm, Sturm, Sucheta Vaidya, Suzanne J. Baker, Taylor, Taylor, Temime-Smaali, Temime-Smaali, Tiberi, Valeria Molinari, Venkatesh, Welcker, Wu, Wu, Wu, Xingang Li, Yada, Yang, Zarghooni   +116 more
core   +8 more sources