Results 61 to 70 of about 9,592 (218)

IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma. [PDF]

PLoS ONE, 2018
Diffuse intrinsic pontine glioma (DIPG) is a universally fatal childhood cancer of the brain. Despite the introduction of conventional chemotherapy and radiotherapy, improvements in survival have been marginal and long-term survivorship is uncommon. Thus,
Noah E Berlow, Matthew N Svalina, Michael J Quist, Teagan P Settelmeyer, Viktor Zherebitskiy, Mari Kogiso, Lin Qi, Yuchen Du, Cynthia E Hawkins, Esther Hulleman, Xiao-Nan Li, Sakir H Gultekin, Charles Keller   +12 more
doaj   +1 more source

Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age [PDF]

, 2015
Pilocytic astrocytoma (PA) is the most common brain tumor in children but is rare in adults, and hence poorly studied in this age group. We investigated 222 PA and report increased aneuploidy in older patients.
Amon, Baker, Barnholtz-Sloan, Barnholtz-Sloan, Chun, Chun, Chun, Cleveland, Collins, Collins, Collins, Compton, Cotman, Coyle, Cui, Di Agostino, Eischen, Eischen, Fletcher, Gandolfi, Gray, Gronych, Grundy, Guadagno, Guadagno, Gutmann, Gutmann, Hasselblatt, Hawkins, Hoffmann, Hoffmann, Hoffmann, Hoffmann, Huether, Jones, Kleihues, Kruchko, Lee, Levine, Li, Liu, Lozano, Lozano, Manfredi, Montagna, Montagna, Paulus, Pekrun, Pellman, Pfister, Prados, Puduvalli, Reifenberger, Rhee, Van den Berghe, Zlotnik   +55 more
core   +5 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Current Murine Models and New Developments in H3K27M Diffuse Midline Gliomas

Frontiers in Oncology, 2019
Diffuse Midline Gliomas with Histone 3-Lysine-27-Methionine (H3K27M) mutation constitute the majority of Diffuse Intrinsic Pontine Glioma (DIPG), which is the most aggressive form of pediatric glioma with a dire prognosis. DIPG are lethal tumors found in
John P. Welby, Tatiana Kaptzan, Anton Wohl, Timothy E. Peterson, Aditya Raghunathan, Desmond A. Brown, Shiv K. Gupta, Liang Zhang, David J. Daniels   +8 more
doaj   +1 more source

Targeted therapy for pediatric diffuse intrinsic pontine glioma: a single-center experience

Therapeutic Advances in Medical Oncology, 2022
Background: Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with a median overall survival (OS) of less than 12 months after diagnosis. Radiotherapy (RT) still remains the mainstay treatment.
Giada Del Baldo, Andrea Carai, Rachid Abbas, Antonella Cacchione, Mara Vinci, Valentina Di Ruscio, Giovanna Stefania Colafati, Sabrina Rossi, Francesca Diomedi Camassei, Nicola Maestro, Sara Temelso, Giulia Pericoli, Emmanuel De Billy, Isabella Giovannoni, Alessia Carboni, Martina Rinelli, Emanuele Agolini, Alan Mackay, Chris Jones, Silvia Chiesa, Mario Balducci, Franco Locatelli, Angela Mastronuzzi   +22 more
doaj   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Pediatric diffuse intrinsic pontine gliomas

Glioma, 2019
Historically, brainstem gliomas have been one of the most difficult types of neoplasms to treat. They comprise 10%–20% of pediatric tumors of the central nervous system. The average age of diagnosis is 7–9 years, without a predilection for gender. The advent of magnetic resonance imaging and radiotherapy has significantly aided in the diagnosis and ...
Huber Said Padilla-Zambrano, Ezequiel Garcia-Ballestas, Amit Agrawal, Maximiliano Paez-Nova, Alfonso I Pacheco-Hernandez, Luis Rafael Moscote-Salazar   +5 more
openaire   +2 more sources

EZH2, HIF-1, and their inhibitors: An overview on pediatric cancers [PDF]

, 2018
During the past decades, several discoveries have established the role of epigenetic modifications and cellularmicroenvironment in tumor growth and progression. One of the main representatives concerning epigenetic modification is the polycomb group (PcG)
Antonello Mai, Diana Bellavia, Elisabetta Ferretti, Elisabetta Ferretti, Giuseppe Battaglia, Marco Papale, Marco Tafani   +6 more
core   +2 more sources