Results 71 to 80 of about 9,592 (218)

Evaluation of clinical cardiac safety of zilurgisertib, an activin receptor‐like kinase‐2 (ALK2) inhibitor, in healthy participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract The oral, small molecule inhibitor of activin receptor‐like kinase‐2, zilurgisertib (INCB000928), is under evaluation in fibrodysplasia ossificans progressiva. Cardiac safety was assessed using electrocardiogram (ECG) parameters and a plasma concentration‐heart rate‐corrected QT (C‐QTc) interval analysis of pooled data from single ascending ...
Yan‐ou Yang, Hong Yang, Xing Liu, Xiaohua Gong, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas [PDF]

, 2014
Studies in pediatric high-grade astrocytomas (HGA) by our group and others have uncovered recurrent somatic mutations affecting highly conserved residues in histone 3 (H3) variants. One of these mutations leads to analogous p.Lys27Met (K27M) mutations in
Albrecht, Steffen, Bechet, Denise, Benlimane, Naciba, David Allis, C., Ellezam, Benjamin, Faury, Damien, Fiset, Pierre-Olivier, Gielen, Gerrit G. H., Jabado, Nada, Kieran, Mark W., Korshunov, Andrey, Lewis, Peter W., Ligon, Keith L., Lu, Chao, Pfister, Stefan M., Pietsch, Torsten, Rousso, Caterina   +16 more
core   +1 more source

Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review

Advances in Radiation Oncology, 2019
Purpose: Diffuse intrinsic pontine glioma (DIPG) is the most aggressive primary pediatric brain tumor, with
Matthew Gallitto, BA, Stanislav Lazarev, MD, Isaac Wasserman, MPH, James M. Stafford, PhD, Suzanne L. Wolden, MD, Stephanie A. Terezakis, MD, Ranjit S. Bindra, MD, PhD, Richard L. Bakst, MD   +7 more
doaj   +1 more source

Focused ultrasound mediated blood–brain barrier opening is safe and feasible in a murine pontine glioma model

Scientific Reports, 2021
Drug delivery in diffuse intrinsic pontine glioma is significantly limited by the blood-brain barrier (BBB). Focused ultrasound (FUS), when combined with the administration of microbubbles can effectively open the BBB permitting the entry of drugs across
Zachary K. Englander, Hong-Jian Wei, Antonios N. Pouliopoulos, Ethan Bendau, Pavan Upadhyayula, Chia-Ing Jan, Eleanora F. Spinazzi, Nina Yoh, Masih Tazhibi, Nicholas M. McQuillan, Tony J. C. Wang, Jeffrey N. Bruce, Peter Canoll, Neil A. Feldstein, Stergios Zacharoulis, Elisa E. Konofagou, Cheng-Chia Wu   +16 more
doaj   +1 more source

Cancer statistics, 2026

CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.
ABSTRACT Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population‐based cancer occurrence and outcomes using data collected by central cancer registries (incidence, through 2022) and the National Center for Health Statistics (mortality, through 2023).
Rebecca L. Siegel, Tyler B. Kratzer, Nikita Sandeep Wagle, Hyuna Sung, Ahmedin Jemal   +4 more
wiley   +1 more source

Diffuse intrinsic pontine glioma: time for therapeutic optimism [PDF]

CNS Oncology, 2014
Diffuse intrinsic pontine glioma (DIPG) is an aggressive tumor that is universally fatal, and to-date we are at a virtual standstill in improving its grim prognosis. Dearth of tissue due to rarity of biopsy has precluded understanding the elusive biology and frustration continues in reproducing faithful animal models for translational research ...
Soumen, Khatua, Wafik, Zaky
openaire   +2 more sources

Hypofractionated re-irradiation for diffuse intrinsic pontine glioma. [PDF]

Pediatr Blood Cancer
AbstractBackgroundRe‐irradiation (reRT) increases survival in locally recurrent diffuse intrinsic pontine glioma (DIPG). There is no standard dose and fractionation for reRT, but conventional fractionation (CF) is typically used. We report our institutional experience of reRT for DIPG, which includes hypofractionation (HF).MethodsWe reviewed pediatric ...
Mankuzhy NP, Tringale KR, Dunkel IJ, Farouk Sait S, Souweidane MM, Khakoo Y, Karajannis MA, Wolden S.   +7 more
europepmc   +3 more sources

FUS BBBO with a Portable FUS System and real time mapping

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Treatment of neurological diseases has been at the forefront of medical research for more than a century with limited success due partly to the blood‐brain barrier (BBB) that impedes both delivery and biodistribution of the drug delivered.
Elisa Konofagou
wiley   +1 more source

Behavioural changes caused by diffuse intrinsic pontine glioma [PDF]

Revista da Associação Médica Brasileira, 2018
UNESP Campus de Botucatu Department of Neurology Psychology and Psychiatry, Distrito de Rubiao Jr, s ...
Pedro Tadao Hamamoto Filho, Igor Barreira Magro, Marco Antonio Zanini   +2 more
openaire   +2 more sources

Neurological update: gliomas and other primary brain tumours in adults. [PDF]

, 2017
The emerging understanding of molecular changes in a wide range of brain tumours has led to a significant shift in how these tumours are diagnosed, managed and treated.
Brandner, S, Jaunmuktane, Z
core   +1 more source