Results 1 to 10 of about 6,667 (221)

Intersection of Brain Development and Paediatric Diffuse Midline Gliomas: Potential Role of Microenvironment in Tumour Growth [PDF]

Brain Sciences, 2018
Diffuse intrinsic pontine glioma (DIPG) is a devastating and incurable paediatric brain tumour with a median overall survival of 9 months. Until recently, DIPGs were treated similarly to adult gliomas, but due to the advancement in molecular and imaging ...
Katie F. Loveson, Helen L. Fillmore
doaj   +3 more sources

DIPG-27. DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) CHALLENGE: FROM GENE EXPRESSION PROFILE TO DRUG [PDF]

Neuro Oncol, 2023
Abstract Diffuse intrinsic pontine glioma (DIPG) accounts for 80% of pediatric brainstem tumors and about 10-20% of all central nervous system tumors in childhood. Despite the adoption of aggressive therapeutic approaches, DIPG remains the leading cause of cancer-related mortality in childhood: prognosis is still poor with more than 90 ...
Scilimati, Antonio, Armenise, Domenico, Baldelli, Olga, Centonze, Antonella, Derri, Davide, Ferorelli, Savina, Miciaccia, Morena, Solidoro, Roberta, Perrone, Maria Grazia   +8 more
europepmc   +2 more sources

Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion [PDF]

Molecular Therapy: Oncolytics, 2017
Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are invasive tumors with poor survival. Oncolytic virotherapy, initially devised as a direct cytotoxic treatment, is now also known to act via immune-mediated mechanisms. Here
Julia V. Cockle, Anke Brüning-Richardson, Karen J. Scott, Jill Thompson, Timothy Kottke, Ewan Morrison, Azam Ismail, Angel M. Carcaboso, Ailsa Rose, Peter Selby, Joe Conner, Susan Picton, Susan Short, Richard Vile, Alan Melcher, Elizabeth Ilett   +15 more
doaj   +8 more sources

DIPG-40. TARGETING MASTER REGULATOR DEPENDENCIES IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) [PDF]

Neuro Oncol, 2020
Abstract Diffuse intrinsic pontine glioma (DIPG) remains a fatal disease with no effective drugs to date. Mutation-based precision oncology approaches are limited by lack of targetable mutations and genetic heterogeneity. We leveraged systems biology methodologies to discover common targetable disease drivers—master regulator proteins ...
Pavisic J, Sethi C, Jones C, Zacharoulis S, Califano A.   +4 more
europepmc   +3 more sources

Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG). [PDF]

J Cancer, 2020
As a highly aggressive pediatric brainstem tumor, diffuse intrinsic pontine glioma (DIPG) accounts for 10% to 20% of childhood brain tumors. The survival rate for DIPG remains very low, with a median survival time as less than one year even under radiotherapy, the current standard treatment.
Dai L, Chen J, Lin Z, Wang Z, Mu S, Qin Z.   +5 more
europepmc   +4 more sources

DIPG-63. RE-IRRADIATION FOR PROGRESSIVE DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): THE SPANISH EXPERIENCE [PDF]

Neuro Oncol
Abstract BACKGROUND Despite advances in its biological understanding, current treatments for diffuse intrinsic pontine glioma (DIPG) have shown minimal impact on overall survival in this fatal disease.
Panizo, Elena, Vazquez-Gomez, Felisa, Perez-Somarriba, Marta, Cruz, Ofelia, Lopez-Ibor, Blanca, Solano, Palma, De las Heras, Blanca Martinez-, Cortés-Hernandez, Marta, Garcia-Ariza, Miguel, Raynero-Mellado, Roberto Carlos, Martinez-Merino, Marta, De Lucio, Ana, Tallón, María, Garrido-Colino, Carmen, Ortiz-Gonzalez, Irene, Portugal, Raquel, Baro, Maria, Gonzalez-Sansegundo, Carmen, Calvo, Felipe, Lassaletta, Alvaro   +19 more
europepmc   +2 more sources

The neurovascular unit in diffuse intrinsic pontine gliomas [PDF]

Free Neuropathology, 2021
Aims: Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a median overall survival of eleven months. Lack of chemotherapy efficacy may be related to an intact blood-brain barrier (BBB).
Fatma E. El-Khouly, Rianne Haumann, Marjolein Breur, Sophie E.M. Veldhuijzen van Zanten, Gertjan J.L. Kaspers, N. Harry Hendrikse, Esther Hulleman, Dannis G. van Vuurden, Marianna Bugiani   +8 more
doaj   +3 more sources

Diffuse intrinsic pontine glioma (DIPG): A review of current and emerging treatment strategies. [PDF]

Cancer Lett
Diffuse intrinsic pontine glioma (DIPG) is a childhood malignancy of the brainstem with a dismal prognosis. Despite recent advances in its understanding at the molecular level, the prognosis of DIPG has remained unchanged. This article aims to review the current understanding of the genetic pathophysiology of DIPG and to highlight promising therapeutic
Weisbrod LJ, Thiraviyam A, Vengoji R, Shonka N, Jain M, Ho W, Batra SK, Salehi A.   +7 more
europepmc   +3 more sources

DIPG-27. Behavioral disturbances as underestimated presenting symptoms in children with Diffuse Intrinsic Pontine Glioma (DIPG) [PDF]

Neuro Oncol, 2022
Abstract PURPOSE: to describe how often behavioral and emotional changes occur at diagnosis in children with DIPG, or precede it. METHODS: the anamnesis, clinical history, psychological evaluation, and onset symptoms of all cases of DIPG diagnosed at Gaslini Institute between January 2010 and December 2020 were reviewed.
Milanaccio, Claudia, Profio, Sonia Di, De Giuseppe, Sara, Ramaglia, Antonia, Verrico, Antonio, Crocco, Marco, Piccolo, Gianluca, Satragno, Camilla, Biassoni, Veronica, Garrè, Maria Luisa   +9 more
europepmc   +2 more sources

DIPG-32. AKT SIGNALING DRIVES RESISTANCE TO ONC201 IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) [PDF]

Neuro Oncol, 2020
Abstract Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive, childhood brainstem cancer with a median overall survival of 10 months post diagnosis. Remarkably, 80–90% of patients harbor recurring point mutation in histone H3, which induces a lysine for methionine substitution at amino acid 27 (H3K27M) in either H3.1 (HIST1H3B
Jackson E, Duchatel R, Mannan A, Hulleman E, Carcaboso A, Monje M, McCowage G, Alvaro F, Dun M.   +8 more
europepmc   +3 more sources