Results 11 to 20 of about 6,667 (221)

Identification of new therapeutic targets and natural compounds against diffuse intrinsic pontine glioma (DIPG). [PDF]

Bioorg Chem, 2020
Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive pediatric brainstem tumor which accounts for about 10-20% of childhood brain tumors. The survival rate for DIPG remains very poor, with a median survival of less than 1 year. The dismal prognosis associated with DIPG has been exacerbated by the failure of a large number of clinical trials ...
Chen J, Lin Z, Barrett L, Dai L, Qin Z.
europepmc   +4 more sources

Re-irradiation for progressive Diffuse Intrinsic Pontine Glioma (DIPG): The Spanish experience

EJC Paediatric Oncology
Introduction: Diffuse intrinsic pontine glioma (DIPG) is the most common malignant brainstem tumour in children. Despite advances in understanding its biology, current treatments have shown minimal impact on overall survival in this fatal disease.
Elena Panizo-Morgado, Felisa Vazquez-Gómez, Marta Perez-Somarriba, Miriam Pavon-Mengual, Andrés Morales-La Madrid, Blanca Lopez-Ibor, Palma Solano, Blanca Martinez de las Heras, Marta Cortés-Hernández, Miguel García-Ariza, Roberto Carlos Raynero-Mellado, Marta Martinez-Merino, Ana de Lucio Delgado, María Tallón-García, Carmen Garrido-Colino, Irene Ortiz-Gonzalez, Raquel Portugal, María Baro-Fernández, Carmen Gonzalez San-Segundo, Felipe Calvo, Alvaro Lassaletta   +20 more
doaj   +2 more sources

DIPG-01. REIRRADIATION PRACTICES FOR DIFFUSE INTRINSIC PONTINE GLIOMA [PDF]

Neuro-Oncology, 2020
Abstract INTRODUCTION Diffuse intrinsic pontine gliomas (DIPG) are a leading cause of brain tumor deaths in children. Current standard of care includes focal radiation therapy (RT). Despite clinical improvement in the majority of patients, the effect is temporary and median survival is less than one ...
Cacciotti, Chantel, Liu, Kevin, Haas-Kogan, Daphne, Warren, Katherine   +3 more
openaire   +1 more source

Chorioallantoic membrane (CAM) assay to study treatment effects in diffuse intrinsic pontine glioma

PLoS ONE, 2022
Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor. While there are a number of in vivo rodent models for evaluating tumor biology and response to therapy, these models require significant time and resources.
Erica A. Power, Jenelys Fernandez-Torres, Liang Zhang, Ruiyi Yaun, Fabrice Lucien, David J. Daniels   +5 more
doaj   +2 more sources

Diffuse intrinsic pontine gliomas in pediatric patients: management updates

Egyptian Journal of Neurosurgery, 2023
Background This review explores how diffuse intrinsic pontine glioma (DIPG) diagnosis and treatment have evolved and are improving. Main body Authors used various sources from 2000 to present time to compile information on diffuse intrinsic pontine ...
Caroline Davidson, Samuel Woodford, Daisy Valle, Grace Parker, Ann-Marie Derias, Carina Copley, Brandon Lucke-Wold   +6 more
doaj   +1 more source

Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas

Nature Communications, 2021
Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in ...
Aaminah Khan, Laura D. Gamble, Dannielle H. Upton, Caitlin Ung, Denise M. T. Yu, Anahid Ehteda, Ruby Pandher, Chelsea Mayoh, Steven Hébert, Nada Jabado, Claudia L. Kleinman, Mark R. Burns, Murray D. Norris, Michelle Haber, Maria Tsoli, David S. Ziegler   +15 more
doaj   +1 more source

Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG registries [PDF]

, 2018
Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and ...
Antonelli, Manila, Antonelli, Manila, Bailey, Simon, Bartels, Ute, Baugh, Joshua, Benesch, Martin, Biassoni, Veronica, Bison, Brigitte, Boddaert, Nathalie, Bouffet, Eric, Broniscer, Alberto, Broxson, Emmett, Calmon, Raphael, Castel, David, Chaney, Brooklyn, Chintagumpala, Murali, Colditz, Niclas, Comito, Melanie, Dholaria, Hetal, Doughman, Renee, Drissi, Rachid, Foreman, Nicholas K., Fouladi, Maryam, Fuller, Christine, Gerber, Nicolas U., Giagnacovo, Marzia, Gielen, Gerrit H., Giraud, G´eraldine, Goldman, Stewart, Gottardo, Nicholas, Grill, Jacques, Grotzer, Michael A., Hargrave, Darren, Hassall, Timothy, Hawkins, Cynthia, Hoffman, Lindsey M., Hoffmann, Marion, Hulleman, Esther, Jabado, Nada, Jadrijevic Cvrlje, Filip, Jones, Blaise, Jones, Chris, Jones, David T. W., Kaspers, Gertjan J. L., Khatua, Soumen, Kieran, Mark W., Kramm, Christof M., Lane, Adam, Leach, James, Leary, Sarah, Massimino, Maura, Miles, Lili, Minturn, Jane, Modena, Piergiorgio, Nazarian, Javad, Packer, Roger, Pfaff, Elke, Pfister, Stefan M., Pietsch, Torsten, Puget, Stephanie, Sanchez, Esther, Shih, Chie-Schin, Solanki, Guirish A., Sophie Carret, Anne, Sturm, Dominik, van Vuurden, Dannis G., Vandertop, William P., Varlet, Pascale, Veldhuijzen van Zanten, Sophie E. M., von Bueren, Andr´e O., Warmuth-Metz, Monika, Warren, Katherine E., Yanez Escorza, Nancy, Ziegler, David S.   +73 more
core   +7 more sources

From Pediatric to Adult Brain Cancer: Exploring Histone H3 Mutations in Australian Brain Cancer Patients

Biomedicines, 2023
Genetic histone variants have been implicated in cancer development and progression. Mutations affecting the histone 3 (H3) family, H3.1 (encoded by HIST1H3B and HIST1H3C) and H3.3 (encoded by H3F3A), are mainly associated with pediatric brain cancers ...
Benedicte Grebstad Tune, Heena Sareen, Branka Powter, Smadar Kahana-Edwin, Adam Cooper, Eng-Siew Koh, Cheok S. Lee, Joseph W. Po, Geoff McCowage, Mark Dexter, Lucy Cain, Geraldine O’Neill, Victoria Prior, Jonathan Karpelowsky, Maria Tsoli, Lars O. Baumbusch, David Ziegler, Tara L. Roberts, Paul DeSouza, Therese M. Becker, Yafeng Ma   +20 more
doaj   +1 more source

DIPG-10. OPTIMAL HDAC INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA [PDF]

Neuro-Oncology, 2020
Abstract As the majority of diffuse intrinsic pontine glioma (DIPG) have H3K27M mutations, epigenetic-targeting agents have been studied, though evaluations have been limited by their model systems, untranslatable drug concentrations, and/or evasive mechanisms of action.
Vitanza, Nicholas, Biery, Matt, Myers, Carrie, Ferguson, Eric, Park, Giulia, Noll, Alyssa, Pakiam, Fiona, Girard, Emily, Morris, Shelli, Cole, Bonnie, Brusniak, Mi-Youn, Mhyre, Andrew, Olson, James   +12 more
openaire   +1 more source

Immunogenic Cell Death Enhances Immunotherapy of Diffuse Intrinsic Pontine Glioma: From Preclinical to Clinical Studies

Pharmaceutics, 2022
Diffuse intrinsic pontine glioma (DIPG) is the most lethal tumor involving the pediatric central nervous system. The median survival of children that are diagnosed with DIPG is only 9 to 11 months.
Guohao Liu, Yanmei Qiu, Po Zhang, Zirong Chen, Sui Chen, Weida Huang, Baofeng Wang, Xingjiang Yu, Dongsheng Guo   +8 more
doaj   +1 more source