Results 21 to 30 of about 6,667 (221)

TP53 Pathway Alterations Drive Radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG) [PDF]

Clinical Cancer Research, 2019
Abstract Purpose: Diffuse intrinsic pontine gliomas (DIPG) are the most severe pediatric brain tumors. Although accepted as the standard therapeutic, radiotherapy is only efficient transiently and not even in every patient.
Werbrouck, Coralie, Evangelista, Cláudia C.S., Lobón-Iglesias, María-Jesús, Barret, Emilie, Le Teuff, Gwénaël, Merlevede, Jane, Brusini, Romain, Kergrohen, Thomas, Mondini, Michele, Bolle, Stéphanie, Varlet, Pascale, Beccaria, Kevin, Boddaert, Nathalie, Puget, Stéphanie, Grill, Jacques, Debily, Marie-Anne, Castel, David   +16 more
openaire   +2 more sources

Interdisciplinary care of children with diffuse midline glioma

Neoplasia: An International Journal for Oncology Research, 2023
Diffuse Midline Glioma (DMG) which includes Diffuse Intrinsic Pontine Glioma (DIPG) is an infiltrative tumor of the midline structures of the central nervous system that demonstrates an aggressive pattern of growth and has no known curative treatment. As
Christina Coleman, Katherine Chen, Alex Lu, Elizabeth Seashore, Schuyler Stoller, Taron Davis, Steve Braunstein, Nalin Gupta, Sabine Mueller   +8 more
doaj   +1 more source

Clinical Presentation, MRI findings and Molecular insights in Diffuse Intrinsic Pontine Gliomas (DIPGs): A Comprehensive Review.

Archives of Pediatric Neurosurgery, 2023
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive and the most common brainstem tumor affecting pediatric patients, with a poor prognosis and limited treatment options. Despite extensive research, the median overall survival remains low, and
Gustavo Novelino Simao
doaj   +1 more source

Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma

Neoplasia: An International Journal for Oncology Research, 2023
Constitutional mismatch repair deficiency (CMMRD) is a cancer predisposition syndrome associated with the development of hypermutant pediatric high-grade glioma, and confers a poor prognosis.
Alyssa Noll, Carrie Myers, Matthew C. Biery, Michael Meechan, Sophie Tahiri, Asmitha Rajendran, Michael E. Berens, Danyelle Paine, Sara Byron, Jiaming Zhang, Conrad Winter, Fiona Pakiam, Sarah E.S. Leary, Bonnie L. Cole, Evangeline R. Jackson, Matthew D. Dun, Jessica B. Foster, Myron K. Evans, Siobhan S. Pattwell, James M. Olson, Nicholas A. Vitanza   +20 more
doaj   +1 more source

DIPG-84. COMPLEMENTARY AND ALTERNATIVE MEDICINE IN DIFFUSE INTRINSIC PONTINE GLIOMA [PDF]

Neuro-Oncology, 2020
Abstract INTRODUCTION Diffuse intrinsic pontine glioma (DIPG) is a rare and aggressive childhood brainstem malignancy with a two-year survival rate of ≤10%. In this international survey study we aim to evaluate the use of complementary and alternative medicine (CAM) in this patient population.
El-Khouly, Fatma, Adil, Syed, Hendrikse, Harry, Kaspers, Gertjan, Kramm, Christof, van Zanten, Sophie Veldhuijzen, van Vuurden, Dannis   +6 more
openaire   +1 more source

Diffuse intrinsic pontine glioma biopsy: A single institution experience [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109626/1/pbc25224 ...
Altinok, Deniz, Bhambhani, Kanta, Miller, Kathy, Poulik, Janet, Rao, Latha, Sood, Sandeep, Wang, Zhihong J.   +6 more
core   +1 more source

DIPG-04. TUMOR CELL-INTRINSIC TIM-3 PROMOTES DIFFUSE INTRINSIC PONTINE GLIOMA TUMORIGENESIS

Neuro-Oncology, 2023
Abstract Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumor and the leading cause of pediatric death caused by cancer. Despite great strides in the understanding of this disease, the median overall survival is still dismal.
Ausejo-Mauleon, Iker, Laspidea, Virginia, de la Nava, Daniel, Nuin, Sara, Palacios-Alonso, Daniel, Marco-Sanz, Javier, Becher, Oren, Jiang, Li, Filbon, Mariella G, Pastor, Fernando, Alonso, Marta M   +10 more
openaire   +1 more source

Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

Cell Reports, 2021
Summary: Diffuse intrinsic pontine glioma (DIPG) is an aggressive and incurable childhood brain tumor for which new treatments are needed. CBL0137 is an anti-cancer compound developed from quinacrine that targets facilitates chromatin transcription (FACT)
Anahid Ehteda, Sandy Simon, Laura Franshaw, Federico M. Giorgi, Jie Liu, Swapna Joshi, Jourdin R.C. Rouaen, Chi Nam Ignatius Pang, Ruby Pandher, Chelsea Mayoh, Yujie Tang, Aaminah Khan, Caitlin Ung, Ornella Tolhurst, Anne Kankean, Elisha Hayden, Rebecca Lehmann, Sylvie Shen, Anjana Gopalakrishnan, Peter Trebilcock, Katerina Gurova, Andrei V. Gudkov, Murray D. Norris, Michelle Haber, Orazio Vittorio, Maria Tsoli, David S. Ziegler   +26 more
doaj   +1 more source

State of affairs in use of steroids in diffuse intrinsic pontine glioma: an international survey and a review of the literature [PDF]

, 2016
Children diagnosed with diffuse intrinsic pontine glioma (DIPG) face a dismal prognosis, with severe neurologic deterioration and inevitable death at a median of 9 months from diagnosis.
Cruz, O, Hargrave, DR, Kaspers, GJL, van Vuurden, DG, van Zanten, SEMV   +4 more
core   +1 more source

Survival rates and prognostic predictors of high grade brain stem gliomas in childhood : a systematic review and meta-analysis [PDF]

, 2017
Diagnosis of a pediatric high grade brain stem glioma is devastating with dismal outcomes. This systematic review and meta-analysis was undertaken to determine the survival rates and assess potential prognostic factors including selected interventions ...
Hassan, Hadeel, Phillips, Robert S, Picton, Susan V, Pinches, Anne   +3 more
core   +1 more source