Results 31 to 40 of about 6,667 (221)

An efficient method for the transduction of primary pediatric glioma neurospheres

MethodsX, 2018
Pediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are rare, but rapidly fatal malignancies of the central nervous system (CNS), and the leading cause of cancer-related death in children.
Michaël H. Meel, Dennis S. Metselaar, Piotr Waranecki, Gertjan J.L. Kaspers, Esther Hulleman   +4 more
doaj   +1 more source

DIPG-01. Targeting p300: A master regulator of childhood diffuse intrinsic pontine glioma (DIPG)

Neuro-Oncology, 2022
Abstract Diffuse intrinsic pontine gliomas (DIPG) are heterogeneous, highly aggressive, accounting for ~10% of all childhood central nervous system tumors that are poorly understood. The heterogeneity of the cell populations could contribute to major variability in tumor growth and chemoresistance followed by inadequate treatment ...
Pinki Chowdhury, Robert Lober
openaire   +1 more source

DIPG-18. IDENTIFICATION OF TARGETABLE PATHWAY DEPENDENCIES IN DIFFUSE INTRINSIC PONTINE GLIOMA [PDF]

Neuro-Oncology, 2020
Abstract Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive paediatric brainstem tumour with a dismal prognosis. Recurrent heterozygous mutations (p.K27M) in Histone H3 variant genes have been identified in the majority of DIPG cases.
Parackal, Sarah, Chong, Wai Chin, Bradshaw, Gabrielle, Sun, Claire, Daniel, Paul, Roussel, Enola, Jayasekara, Samantha, Crombie, Duncan, Firestein, Ron, Cain, Jason   +9 more
openaire   +1 more source

Diffuse intrinsic pontine glioma: poised for progress [PDF]

, 2012
Diffuse intrinsic pontine gliomas (DIPGs) are amongst the most challenging tumors to treat. Surgery is not an option, the effects of radiation therapy are temporary, and no chemotherapeutic agent has demonstrated significant efficacy.
Katherine E. Warren
core   +2 more sources

Immunotherapy Approaches for the Treatment of Diffuse Midline Gliomas [PDF]

, 2022
Diffuse midline gliomas (DMG) are a highly aggressive and universally fatal subgroup of pediatric tumors responsible for the majority of childhood brain tumor deaths.
Baird, Lissa, Becher, Oren J, Bernstock, Joshua D, Essayed, Walid Ibn, Filbin, Mariella G, Filipski, Katharina, Friedman, Gregory K, Gessler, Florian A, Hashizume, Rintaro, Hoffman, Samantha E, Kang, Kyung-Don, Kappel, Ari D, Klinger, Neil V, Olsen, Hannah E, Schlappi, Charles W, Totsch, Stacie K, Valdes, Pablo A   +16 more
core   +2 more sources

Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review

Advances in Radiation Oncology, 2019
Purpose: Diffuse intrinsic pontine glioma (DIPG) is the most aggressive primary pediatric brain tumor, with
Matthew Gallitto, BA, Stanislav Lazarev, MD, Isaac Wasserman, MPH, James M. Stafford, PhD, Suzanne L. Wolden, MD, Stephanie A. Terezakis, MD, Ranjit S. Bindra, MD, PhD, Richard L. Bakst, MD   +7 more
doaj   +1 more source

In vitro drug response and efflux transporters associated with drug resistance in pediatric high grade glioma and diffuse intrinsic pontine glioma. [PDF]

PLoS ONE, 2013
Pediatric high-grade gliomas (pHGG), including diffuse intrinsic pontine gliomas (DIPG), are the leading cause of cancer-related death in children. While it is clear that surgery (if possible), and radiotherapy are beneficial for treatment, the role of ...
Susanna J E Veringa, Dennis Biesmans, Dannis G van Vuurden, Marc H A Jansen, Laurine E Wedekind, Ilona Horsman, Pieter Wesseling, William Peter Vandertop, David P Noske, GertJan J L Kaspers, Esther Hulleman   +10 more
doaj   +1 more source

Development of the SIOPE DIPG network, registry and imaging repository : a collaborative effort to optimize research into a rare and lethal disease [PDF]

, 2017
Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival.
Bailey, S, Barkhof, F, Baugh, J, Biassoni, V, Bison, B, Calmon, R, Cannarozzo, A, Castel, D, Chaney, B, Colditz, N, Cruz, O, Damen-Korbijn, CM, De Jongh, D, De Wolf, R, Deak, L, Emmerik, J, Entz-Werle, N, Fouladi, M, Gandola, L, Garami, M, Gerber, N, Gielen, GH, Gil-da-Costa, MJ, Giraud, G, Grill, J, Grundy, R, Hargrave, DR, Hauser, P, Hayden, T, Hoffmann, M, Holm, S, Hulleman, E, Jacobs, S, Jadrijevic-Cvrlje, F, Janssens, GO, Jones, C, Jones, DT, Kaspers, GJ, Kattamis, A, Kebudi, R, Kitanovski, L, Kivivuori, SM, Kramm, CM, Leblond, P, Lieverst, JA, Lopez-Aguilar, E, Massimino, M, members of the SIOPE DIPG Network, ., Morales La Madrid, A, Noltes, J, Nysom, K, Pears, J, Pentikainen, V, Perek-Polnik, M, Rutkauskiene, G, Sanchez Aliaga, E, Shats, L, Slavc, I, Sturm, D, Sumerauer, D, Thorarinsdottir, HK, Torsvik, IK, Van Dijk, J, Van Gool, S, van Vuurden, DG, Vandertop, WP, Varlet, P, Veldhuijzen van Zanten, SE, von Bueren, AO, Warmuth-Metz, M, Zapata-Tarres, M, Zheludkova, O   +71 more
core   +5 more sources

Investigating The Potential for Immunotherapies in Diffuse Intrinsic Pontine Glioma (DIPG)

Journal of Student Research, 2022
Cancer is the second leading cause of death worldwide, and has significant economic, social, and emotional effects. Diffuse Intrinsic Pontine Glioma (DIPG), a rare type of cancer, is a devastating pediatric brain tumor that currently has no effective therapy.
Anika Verma, Alexander Wesolowski
openaire   +1 more source

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

Nature Communications, 2019
Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase gene ...
Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Ángel M. Carcaboso, Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra   +14 more
doaj   +1 more source