Results 41 to 50 of about 6,667 (221)

Current Murine Models and New Developments in H3K27M Diffuse Midline Gliomas

Frontiers in Oncology, 2019
Diffuse Midline Gliomas with Histone 3-Lysine-27-Methionine (H3K27M) mutation constitute the majority of Diffuse Intrinsic Pontine Glioma (DIPG), which is the most aggressive form of pediatric glioma with a dire prognosis. DIPG are lethal tumors found in
John P. Welby, Tatiana Kaptzan, Anton Wohl, Timothy E. Peterson, Aditya Raghunathan, Desmond A. Brown, Shiv K. Gupta, Liang Zhang, David J. Daniels   +8 more
doaj   +1 more source

Clinicopathology & Molecular Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) in Children - Insights from Past, Present, and Future Directions [PDF]

, 2022
Diffuse Intrinsic Pontine Glioma, or DIPG, is a rare, highly aggressive, heterogeneous group of brainstem tumors. Around 10-20% of primary brain tumors are considered pediatric brain tumors, of which 10-15% are diffuse brainstem tumors.
Biswas, Arupam
core   +2 more sources

DIPG-33. CHARACTERIZING THE NEURO-VASCULAR UNIT IN DIFFUSE INTRINSIC PONTINE GLIOMA [PDF]

Neuro-Oncology, 2020
Abstract Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a median overall survival of eleven months. Lack of chemotherapy efficacy may be related to an intact blood-brain-barrier (BBB). In this study we aim to compare the neuro-vascular unit (NVU) of DIPG to healthy pons tissue. End-stage DIPG autopsy samples (
El-Khouly, Fatma E, Haumann, Rianne, Breur, Marjolein, van Zanten, Sophie E M Veldhuijzen, Kaspers, Gertjan J L, Hendrikse, N Harry, Hulleman, Esther, van Vuurden, Dannis G, Bugiani, Marianna   +8 more
openaire   +1 more source

Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma

Frontiers in Pharmacology, 2017
Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating
Wenyong Long, Yang Yi, Yang Yi, Shen Chen, Shen Chen, Qi Cao, Wei Zhao, Wei Zhao, Qing Liu   +8 more
doaj   +1 more source

Approaches Toward Improving the Prognosis of Pediatric Patients With Glioma: Pursuing Mutant Drug Targets With Emerging Small Molecules [PDF]

, 2014
Gliomas represent approximately 70% of all pediatric brain tumors and most of these are of astrocytic lineage, furthermore, malignant or high-grade astrocytoma account for approximately 20% of pediatric astrocytoma. Treatment options for pediatric glioma
Snape, Timothy J., Warr, Tracy
core   +1 more source

Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma [PDF]

, 2017
Recent exciting work partly through The Cancer Genome Atlas has implicated epigenetic mechanisms including histone modifications in the development of both pediatric and adult high-grade glioma (HGG).
Kurian, Kathreena M, Lowis, Stephen P, Malik, Karim, Singleton, Will G B, Williams, Maria J   +4 more
core   +1 more source

DIPG-22. DISSECTING THE ONCOGENIC ROLE OF FOXR2 IN DIFFUSE INTRINSIC PONTINE GLIOMA [PDF]

Neuro-Oncology, 2020
Abstract BACKGROUND Diffuse intrinsic pontine gliomas (DIPGs) pose particular challenges for treatment. We recently completed a genomic analysis of close to 200 DIPGs and high-grade gliomas. We identified that nearly 10% of all DIPGs have increased expression of the fork head domain transcription ...
Tsai, Jessica W, Patel, Smruti K, Bear, Heather, Dubois, Frank, Khadka, Prasidda, Lu, Sophie, Gonzalez, Elizabeth, Ligon, Keith, Bandopadhayay, Pratiti, Phoenix, Timothy N   +9 more
openaire   +1 more source

Functionalized Macrophage Exosomes with Panobinostat and PPM1D‐siRNA for Diffuse Intrinsic Pontine Gliomas Therapy

Advanced Science, 2022
Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain tumor. Mutation of p53‐induced protein phosphatase 1 (PPM1D) in DIPG cells promotes tumor cell proliferation, and inhibition of PPM1D expression in DIPG cells with PPM1D mutation
Shaobo Shan, Junge Chen, Yu Sun, Yongchao Wang, Bozhang Xia, Hong Tan, Changcun Pan, Guocan Gu, Jie Zhong, Guangchao Qing, Yuxuan Zhang, Jinjin Wang, Yufei Wang, Yi Wang, Pengcheng Zuo, Cheng Xu, Fangzhou Li, Weisheng Guo, Lijun Xu, Meiwan Chen, Yubo Fan, Liwei Zhang, Xing‐Jie Liang   +22 more
doaj   +1 more source

Lagophthalmos- A Rare Presenting Sign in a Case of Childhood Pontine Glioma [PDF]

Journal of Clinical and Diagnostic Research, 2020
Brain stem glioma is a rare central nervous system tumour arising from glial cells which occur mostly in children. Diffuse Intrinsic Pontine Gliomas (DIPG) and Focal glioma are the two types of pontine glioma. DIPGs are highly aggressive.
N Gayathri, G Premnath, S Kiruthika, Manoj Vasudevan, Geeta Anusha Loya   +4 more
doaj   +1 more source

Cell migration in paediatric glioma; characterisation and potential therapeutic targeting [PDF]

, 2015
Background: Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are highly aggressive brain tumours. Their invasive phenotype contributes to their limited therapeutic response, and novel treatments that block brain tumour ...
A Broniscer, A Brüning-Richardson, A M Carcaboso, A Melcher, B Wehrle-Haller, C Jones, CA Grimes, D Del Duca, DN Louis, E Ilett, G Mehta, H Eldar-Finkelman, J Johnson, J Levesley, J Luo, J V Cockle, JG Wakefield, KE Warren, L Meijer, L P Steel, M Vinci, MO Nowicki, OT Fackler, PA Agudelo-Garcia, PB Mitchell, R Hoessel, S E Lawler, S Picton, S Short, SJ Smith, SP Williams, SP Williams, T Demuth, T Siegal, T Sun, VW Van Beusechem, XH Ma   +36 more
core   +2 more sources