Brainstem Glioma in Adults [PDF]
, 2016 Brainstem gliomas are not nearly as common in adults as they are in children. They are likely the final common consequence not of a single disease process but of several. They can be difficult to diagnose, and are challenging to treat.
Jethro Hu +2 more
core +2 more sources
A phase I/II study of gemcitabine during radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma [PDF]
, 2017 The purpose of this phase I/II, open-label, single-arm trial is to investigate the safety, tolerability, maximum tolerated dose and preliminary efficacy of the potential radiosensitizer gemcitabine, administered concomitantly to radiotherapy, in children
Bakker, D.P. (Dewi P.) +10 more
core +1 more source
Променева терапія пухлин стовбура головного мозку у дітей [PDF]
, 2022 Background. Tumors of the central nervous system occupy the first place in the structure of causes of death from malignant tumors among children. The tumors of brain stem structures account for 10 to 15% of all intracranial neoplasms in this age group ...
Вінцевич, Л.В. +6 more
core +2 more sources
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
core +1 more source
DIPG-03. THERAPEUTIC TARGETING OF TRANSCRIPTIONAL ELONGATION IN DIFFUSE INTRINSIC PONTINE GLIOMA [PDF]
Neuro-Oncology, 2020 Abstract Diffuse intrinsic pontine glioma (DIPG) is highly aggressive brain stem tumor and needed to develop novel therapeutic agents for the treatment. The super elongation complex (SEC) is essential for transcription elongation through release of RNA polymerase II (Pol II). We found that AFF4, a scaffold protein of the SEC, is required
Katagi, Hiroaki +16 more
openaire +1 more source
Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma
Acta Neuropathologica Communications, 2018 Diffuse intrinsic pontine glioma (DIPG) is a universally fatal malignancy of the childhood central nervous system, with a median overall survival of 9–11 months.
Grant L. Lin +5 more
doaj +1 more source
Diffuse intrinsic pontine glioma: current insights and future directions
Chinese Neurosurgical Journal, 2021 Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor and the leading cause of brain tumor–related death in children. As several clinical trials over the past few decades have led to no significant improvements in outcome, the current
Dilakshan Srikanthan +5 more
doaj +1 more source
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. [PDF]
, 2017 We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases.
Adam Resnick +116 more
core +8 more sources
A homogeneous treatment for non-DIPG diffuse midline glioma [PDF]
, 2023 Introduction: The H3K27M-mutant diffuse midline glioma (DMG) was first included in the World Health Organization (WHO) Classification of central nervous system (CNS) tumors in 2016, and confirmed in its fifth edition.
Antonelli, Manila +10 more
core +1 more source
Case Report: Low-grade glioma with NF1 loss of function mimicking diffuse intrinsic pontine glioma
Frontiers in SurgeryIntrinsic, expansile pontine tumors typically occur in the pediatric population. These tumors characteristically present as diffuse intrinsic pontine glioma (DIPG), which is now considered as diffuse midline glioma (DMG), H3K27-mutated of the pons.
Joshua D. Bernstock +13 more
doaj +1 more source