Results 81 to 90 of about 6,667 (221)

Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG

Epigenetics & Chromatin, 2022
Background The histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG).
Nichole A. Lewis, Rachel Herndon Klein, Cailin Kelly, Jennifer Yee, Paul S. Knoepfler   +4 more
doaj   +1 more source

Diffuse intrinsic pontine glioma: Insights into oncogenesis and opportunities for targeted therapy

Pediatric Hematology Oncology Journal, 2023
Diffuse intrinsic pontine glioma (DIPG) is a lethal brainstem tumor that most commonly occurs in young children between the ages of five and ten. DIPG is the leading cause of brain tumor-related death in childhood, with most patients succumbing to the ...
Andrew Groves, Pratiti Bandopadhayay, Tabitha M. Cooney   +2 more
doaj   +1 more source

CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma. [PDF]

, 2020
BackgroundLong non-coding RNAs (lncRNAs) exhibit highly cell type-specific expression and function, making this class of transcript attractive for targeted cancer therapy.
Akeson, Mark, Birk, Harjus S, Gupta, Nalin, He, Daniel, Hong, Sung Jun, Horlbeck, Max A, Jain, Miten, Koontz, Mark, Lien, Brian V, Lim, Daniel A, Liu, S John, Malatesta, Martina, Monje, Michelle, Olsen, Hugh E, Pedraza, Leslie, Raleigh, David R, Saha, Parna, Seo, Kyounghee, Thombare, Shivani S, Ullian, Erik M, Weissman, Jonathan S   +20 more
core   +1 more source

ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma [PDF]

, 2023
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPGs), are the most lethal of childhood cancers. Palliative radiotherapy is the only established treatment, with median patient survival of 9-11 months.
Beitaki, Tyrone S, Chong, Wai Chin, Day, Bryan, Douglas, Alicia M, Duchatel, Ryan J, et al, Findlay, Izac J, Firestein, Ron, Game, Shaye, Germon, Zacary P, Govender, Dinisha, Hansford, Jordan R, Howlett, Meegan, Jackson, Evangeline R, Jayasekara, W Samantha Nilanthi, Kearney, Padraic S, Le Grand, Marion, Mannan, Abdul, Manoharan, Neevika, McCowage, Geoffrey B, McEwen, Holly P, Nagabushan, Sumanth, Nazarian, Javad, Nixon, Brett, Parackal, Sarah, Patabendige, Adjanie, Persson, Mika L, Skerrett-Byrne, David A, Smith, Nathan D, Staudt, Dilana E, Yadavilli, Sridevi   +30 more
core   +1 more source

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

Cancer Science, Volume 116, Issue 12, Page 3250-3265, December 2025.
This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved questions, including isozyme‐specific roles and mechanisms for escaping regulations, and propose mechanistic and translational strategies to design IMPDH‐targeted
Aki Ogawa‐Iio, Koh Takeuchi, Keita Shigemi, Michelle Jane Genoveso, Hiroaki Niitsu, Iemasa Koh, Yusei Ota, Keita Yamane, Takao Hinoi, Natsuki Osaka, Masashi Oshima, Tomohiro Ishikawa, Tomoyuki Mizuno, Manabu Natsumeda, Kensuke Tateishi, Rintaro Hashizume, Satoru Osuka, Susumu Goyama, Tomoharu Yasuda, Toshiya Senda, Atsuo T. Sasaki   +20 more
wiley   +1 more source

Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma

Cell & Bioscience, 2017
Background Diffuse intrinsic pontine glioma is an infiltrative, often high-grade glioma of the brainstem that is not amenable to surgical resection. The current treatment of DIPG by radiation therapy showed dramatically improvement of patient’s condition,
Yaqin Zhang, Weijie Dong, Junying Zhu, Lizhu Wang, Xinjian Wu, Hong Shan   +5 more
doaj   +1 more source

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics [PDF]

, 2016
INTRODUCTION: Diffuse intrinsic pontine glioma (DIPG) and midline high-grade glioma (mHGG) are lethal childhood brain tumors. Spatial genomic heterogeneity has been well-described in adult HGG but has not been comprehensively characterized in pediatric ...
Arun Ramani, Blaise Jones, Bruce Aronow, Charles Stevenson, Cynthia E. Hawkins, David Witte, James Leach, Lili Miles, Lindsey M. Hoffman, Lionel Chow, Mariko DeWire, Maryam Fouladi, Michael Brudno, Pawel Buczkowicz, Phillip Dexheimer, Q. Richard Lu, Rachid Drissi, Ralph Salloum, Scott Ryall, Shiva Senthil Kumar, Trent Hummel   +20 more
core   +1 more source

Decoding Gene Expression Changes in Cerebral Tumors: Before and After Radiotherapy

Medicinal Research Reviews, Volume 45, Issue 6, Page 1651-1661, November 2025.
ABSTRACT Cerebral tumors, particularly in pediatric patients, pose a significant challenge in oncology. Radiotherapy is a crucial component of the multimodal treatment approach for these tumors. Understanding the molecular basis of these tumors, particularly their response to radiotherapy, is crucial for improving treatment outcomes and patient ...
Ahana Maitra, Morena Miciaccia, Manuela Mandorino, Domenico Armenise, Olga Maria Baldelli, Savina Ferorelli, Ludmila Papusha, Alexander Druy, Maria Grazia Perrone, Antonio Scilimati   +9 more
wiley   +1 more source

Invaders Exposed: Understanding and Targeting Tumor Cell Invasion in Diffuse Intrinsic Pontine Glioma

Frontiers in Oncology, 2020
Diffuse Intrinsic Pontine Glioma (DIPG) is a rare, highly aggressive pediatric brain tumor that originates in the pons. DIPG is untreatable and universally fatal, with a median life expectancy of less than a year.
T. A. Kluiver, T. A. Kluiver, T. A. Kluiver, M. Alieva, M. Alieva, M. Alieva, D. G. van Vuurden, Ellen J. Wehrens, Ellen J. Wehrens, Ellen J. Wehrens, Anne C. Rios, Anne C. Rios, Anne C. Rios   +12 more
doaj   +1 more source

DIPG-50. INSIGHTS INTO TUMORIGENESIS OF DIFFUSE INTRINSIC PONTINE GLIOMA-ONCOHISTONE AND SIGNALING

Neuro-Oncology, 2023
Abstract Diffuse intrinsic pontine glioma (DIPG) is a rare and incurable pediatric brain cancer with survival of less than one year. Understanding the tumorigenesis mechanisms of DIPG and identifying potential therapeutic strategy are major research foci in the DIPG field. The most lethal subtype of diffuse intrinsic pontine glioma (DIPG)
Sun, Ye, Yan, Kun, Wang, Dan, Zhou, Wei, Wang, Yi, Xu, Cheng, Han, Yujie, Tang, Yujie, Zhang, Liwei, Xi, Qiaoran   +9 more
openaire   +1 more source