Results 71 to 80 of about 30,853 (284)

Implementing the Three-Equation Method of Measuring Single Breath Carbon Monoxide Diffusing Capacity

open access: yesCanadian Respiratory Journal, 1996
Conventional methods of measuring the single breath diffusing capacity of the lung for carbon monoxide (DLcoSB) are based on the Krogh equation, which is valid only during breath holding.
Brian L Graham   +2 more
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

Mexican Hispanics show significant improvement in lung function approximately 1 year after having severe COVID‐19

open access: yesExperimental Physiology
The long‐term effects of COVID‐19 on lung function are not understood, especially for periods extending beyond 1 year after infection. This observational, longitudinal study investigated lung function in Mexican Hispanics who experienced severe COVID‐19,
Arturo Cortes‐Telles   +4 more
doaj   +1 more source

Nutritional status and airflow obstruction: two independent contributors to CO diffusing capacity impairment in COPD

open access: yesMonaldi Archives for Chest Disease, 2005
Background. The association between weight loss and Chronic Obstructive Pulmonary Disease (COPD) has been recognised from many years. Based on the evidence that nutritional status reflects metabolic disturbances in COPD, the relationship between body ...
S. Baldi   +7 more
doaj   +1 more source

Uniqueness of diffusion operators and capacity estimates [PDF]

open access: yesJournal of Evolution Equations, 2013
Let $ $ be a connected open subset of $\Ri^d$. We analyze $L_1$-uniqueness of real second-order partial differential operators $H=-\sum^d_{k,l=1}\partial_k\,c_{kl}\,\partial_l$ and $K=H+\sum^d_{k=1}c_k\,\partial_k+c_0$ on $ $ where $c_{kl}=c_{lk}\in W^{1,\infty}_{\rm loc}( ), c_k\in L_{\infty,{\rm loc}}( )$, $c_0\in L_{2,{\rm loc}}( )$ and $C(x)=(
openaire   +4 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

open access: yesMolecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan   +4 more
wiley   +1 more source

Acute effects of combined exercise and oscillatory positive expiratory pressure therapy on sputum properties and lung diffusing capacity in cystic fibrosis: a randomized, controlled, crossover trial

open access: yesBMC Pulmonary Medicine, 2018
Background Regular airway clearance by chest physiotherapy and/or exercise is critical to lung health in cystic fibrosis (CF). Combination of cycling exercise and chest physiotherapy using the Flutter® device on sputum properties has not yet been ...
Thomas Radtke   +7 more
doaj   +1 more source

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