Results 81 to 90 of about 108,013 (319)

European Respiratory Society International Congress best abstract preview from the allied respiratory professionals from assembly 9 [PDF]

, 2018
The 28th European Respiratory Society (ERS) International Congress [2018] in Paris features interesting research findings within the allied respiratory professional assembly (assembly 9).
Blonshine, Jason, Cruz, Joana, De Brandt, Jana, Sajnic, Andreja   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

COMPARING DIFFUSING CAPACITY REFERENCE EQUATION PERFORMANCE IN EVALUATING ABNORMAL DLCO IN POST-PNEUMONIA UGANDAN ADULTS [PDF]

, 2023
Katerina L. Byanova, JESSICA FITZPATRICK, Ingvar Sanyu, Josephine Zawedde, Patrick Byanyima, J.R. Branchini, Michelle Zhang, Rebecca Abelman, Abdulwahab Sessolo, Nirav R. Bhakta, J A Lin, Peter W. Hunt, William Worodria, LAURENCE HUANG   +13 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Gas transfer and pulmonary function tests in women with disseminated lupus erythematosus

ARYA Atherosclerosis, 2012
   BACKGROUND: Systemic lupus involves different body organs including lungs. However, there is limited information on the systemic lupus without respiratory symptoms.
Babak Amra, Bijan Iraj, Zahra Seyyed Benakdar, Hamid Sanei, Mohammad Golshan   +4 more
doaj  

Adaptation of Autocatalytic Fluctuations to Diffusive Noise

, 2000
Evolution of a system of diffusing and proliferating mortal reactants is analyzed in the presence of randomly moving catalysts. While the continuum description of the problem predicts reactant extinction as the average growth rate becomes negative ...
A. Kolmogoroff, A. Okubo, B.I. Shklovskii, D. Forster, D. S. Fisher, D.C. Mattis, D.R. Nelson, E. Bettelheim, E. Medina, F. Schlogel, H.K. Janssen, H.K. Janssen, I. Jensen, J.D. Murray, J.L. Cardy, J.L. Cardy, K.A. Dahmen, L. Peliti, L.E. Reichl, M. Doi, M. Kardar, M. Kardar, N. M. Shnerb, N.M. Shnerb, O. Agam, P. Grassberger, P. Grassberger, P.W. Anderson, R. Durrett, R.A. Fisher, S. Solomon, T. Halpin-Healy, W. Kinzel, Y. Louzoun   +33 more
core   +1 more source

Four-Dimensional Neuronal Signaling by Nitric Oxide: A Computational Analysis [PDF]

, 2000
Nitric oxide (NO) is now recognized as a transmitter of neurons that express the neuronal isoform of the enzyme nitric oxide synthase. NO, however, violates some of the key tenets of chemical transmission, which is classically regarded as occurring at ...
Husbands, Phil, O'Shea, Michael, Philippides, Andy   +2 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source