Results 111 to 120 of about 2,067,464 (306)

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei, Elena Parrini, Claudia Bianchini, Maria Luisa Ricci, Renzo Guerrini   +4 more
wiley   +1 more source

Comparing T2 weighted images/diffusion weighted imaging and T2 weighted images/dynamic contrast enhanced MRI for endometrial carcinoma myometrial invasion

The Egyptian Journal of Radiology and Nuclear Medicine, 2017
Objectives: To evaluate accuracy of combined T2 and diffusion weighted images (DWI) in comparison to combined T2WI and dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) for assessment of the depth of myometrial invasion.
Mohamed Aboul-Fotouh Mourad, Elsayed M. Mousa   +1 more
doaj   +1 more source

Comparison of block and event-related experimental designs in diffusion-weighted functional MRI

, 2013
Purpose: To compare diffusion-weighted functional magnetic resonance imaging (DfMRI), a novel alternative to the blood oxygenation level-dependent (BOLD) contrast, in a functional MRI ...
McMahon, Katie L., David C. Reutens, Reutens, D.C., Julia Hocking, Hocking, Julia, Williams, R.J., McMahon, K.L., Katie L. McMahon, Williams, Rebecca J., Reutens, David C., Hocking, J., Rebecca J. Williams   +11 more
core   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Transformer’s Role in Brain MRI: A Scoping Review

IEEE Access
Magnetic Resonance Imaging (MRI) is a critical imaging technique that provides detailed visualization of internal structures without harmful radiation. This review focuses on key MRI modalities, including T1-weighted and T2-weighted imaging, functional ...
Mansoor Hayat, Supavadee Aramvith
doaj   +1 more source

Diffusion Tensor Imaging: on the assessment of data quality - a preliminary bootstrap analysis [PDF]

, 2003
In the field of nuclear magnetic resonance imaging, diffusion tensor imaging (DTI) has proven an important method for the characterisation of ultrastructural tissue properties.
Heim, Stefan, Heim, Susanne, Hahn, Klaus R., Auer, Dorothee P., Hahn, Klaus   +4 more
core   +1 more source

Thymosin Alpha‐1 Provides Direct Neuroprotection by Engaging the Orexin Receptor HCRTR1 to Suppress Neuronal Necroptosis

Advanced Science, EarlyView.
In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang, Shisi Wang, Liubin Zhang, Mengyan Hu, Xiaotao Su, Yuxin Liu, Qin Qin, Haotong Yi, Liling Yuan, Wei Cai, Lei Wei, Zhengqi Lu   +11 more
wiley   +1 more source

Diagnostic value of diffusion weighted magnetic resonance image in early ankylosing spondylitis

The Egyptian Journal of Radiology and Nuclear Medicine, 2014
Background: Diffusion-weighted MRI (DW-MRI) shows the early changes in microscopical movement of water molecules, hence diagnosis of early sacroiliitis which is one of the diagnostic criteria of seronegative spondyloarthropathies. Objective: To determine
Khaled Dewan, Hanan El-saadany
doaj   +1 more source

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source