Results 41 to 50 of about 2,907,472 (310)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Microstructure and mechanical properties of diffusion bonded joints of high-entropy alloy Al5(HfNbTiZr)95 and TC4 titanium alloy

Journal of Materials Research and Technology, 2021
TC4 (Ti–6Al–4V) titanium alloy and Al5(HfNbTiZr)95 refractory high-entropy alloy were successfully diffusion bonded at a temperature range of 800–1000 °C for 60 min under 5 MPa.
Yu Peng, Jinglong Li, Junmiao Shi, Shiwei Li, Jiangtao Xiong   +4 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Effects of diffusion bonding temperature and holding time on the microstructure and strength of diffusion bonded B4C-HfB2-SiC composite ceramic joint

Journal of Materials Research and Technology
Diffusion bonding of B4C-HfB2-SiC composite ceramic with Ti and NiCoCr medium-entropy alloy as the composite interlayer material was studied in this work. The effects of diffusion bonding temperature and holding time on the interfacial microstructure and
Langxiang Zhong, Biao Liang, Chengmin Chen, Kuijing Song, Zhihong Zhong   +4 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Low-Temperature Diffusion of Au and Ag Nanolayers for Cu Bonding

Applied Sciences, 2023
With the recent rapid development of IT technology, the demand for multifunctional semiconductor devices capable of high performance has increased rapidly, and the miniaturization of such devices has also faced limitations. To overcome these limitations,
Sangmin Lee, Sangwoo Park, Sarah Eunkyung Kim   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Microstructural Evolution in Nonvacuum Solid-State Diffusion Bonded Joints of AA2219

Advances in Materials Science and Engineering, 2023
Solid-state diffusion bonding of AA2219 alloy is carried out under the nonvacuum condition to form AA2219/AA2219 joints. In the currently adopted method, AA2219 alloys are joined under the bonding temperature of 450–500°C, bonding pressure of 10 MPa, and
Manjunath Vatnalmath, V. Auradi, V. Bharath, Madeva Nagaral, N. Nagaraj, A. Haiter Lenin   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Microstructure and strengthening mechanism of diffusion bonding joints of 6063 aluminum alloy under the monomolecular surface protection of α-terpineol

Journal of Materials Research and Technology
6063 aluminum alloy is often used in the manufacture of microchannel heat exchangers, which are formed by diffusion bonding to connect laminates, and diffusion bonding is a key technology that determines the production quality.
Jiafen Song, Lichi Ma, Shiming Xu, Yu Peng, Jiangtao Xiong, Jinglong Li   +5 more
doaj   +1 more source