Results 111 to 120 of about 24,691,873 (342)

Diffusion in a multi-component Lattice Boltzmann Equation model

, 1996
Diffusion phenomena in a multiple component lattice Boltzmann Equation (LBE) model are discussed in detail. The mass fluxes associated with different mechanical driving forces are obtained using a Chapman-Enskog analysis.
A. K. Gunstensen, C. Appert, D. H. Rothman, D. O. Martínez, E. G. Flekko/y, E. G. Flekko/y, Gary Doolen, H. Chen, P. L. Bhatnagar, R. B. Bird, R. Benzi, R. Holme, S. Chapman, S. Hou, S. Wolfram, U. Frisch, X. Shan, X. Shan, X. Shan, Xiaowen Shan, Y. H. Qian   +20 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Modelling diffusional transport in the interphase cell nucleus

, 2007
In this paper a lattice model for diffusional transport of particles in the interphase cell nucleus is proposed. Dense networks of chromatin fibers are created by three different methods: randomly distributed, non-interconnected obstacles, a random walk ...
Annika Wedemeier, Chen-Xu Wu, Holger Merlitz, Jörg Langowski, Lukacs G., Ptashne M., von Hippel P. H.   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Continuous-time random walk theory of superslow diffusion

, 2010
Superslow diffusion, i.e., the long-time diffusion of particles whose mean-square displacement (variance) grows slower than any power of time, is studied in the framework of the decoupled continuous-time random walk model.
Denisov, S. I., Kantz, H.
core   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Unfolding Rates for the Diffusion-Collision Model

, 2001
In the diffusion-collision model, the unfolding rates are given by the likelihood of secondary structural cluster dissociation. In this work, we introduce an unfolding rate calculation for proteins whose secondary structural elements are $\alpha$-helices,
A. Fersht, A. Szabo, A.R. Dinner, B. Lee, B.H. Zimm, C. Chothia, Chris Beck, D. Chandler, D.L. Weaver, E. Lacroix, G.H. Weiss, J.K. Meyers, L. Regan, M. Karplus, M. Karplus, R.E. Burton, R.V. Pappu, V. Munoz, V. Munoz, V. Munoz, V. Munoz, V. Munoz, Xavier Siemens   +22 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Turing instabilities in a mathematical model for signaling networks

, 2011
GTPase molecules are important regulators in cells that continuously run through an activation/deactivation and membrane-attachment/membrane-detachment cycle. Activated GTPase is able to localize in parts of the membranes and to induce cell polarity.
AB Goryachev, AB Jaffe, AJ Koch, Andreas Rätz, B Sönnichsen, BL Grosshans, C Garmendia-Torres, C Landsberg, G Dziuk, HM Lommerse Piet, JD Murray, JL Bos, K John, L Brusch, M Postma, Matthias Röger, R Lipp, R Wedlich-Soldner, RS Goody, S Pfeffer, S Pfeffer, S Vey, SJ Altschuler, T Butler, U Keller Jürgen, VL Katanaev, Y Mori, Z Guo   +27 more
core   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source