Results 71 to 80 of about 24,691,873 (342)
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Fine-Grained Human Hair Segmentation Using a Text-to-Image Diffusion Model
IEEE AccessHuman hair segmentation is essential for face recognition and for achieving natural transformation of style transfer. However, it remains a challenging task due to the diverse appearances and complex patterns of hair in image. In this study, we propose a
Dohyun Kim +3 more
doaj +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
IEEE AccessThe Vehicle Routing Problem with Multiple Soft Time Windows (VRPMSTW) is a challenging combinatorial optimization problem where a fleet of vehicles must deliver goods to a set of customers, adhering to time windows while minimizing costs.
Yu Qiao, Jianjun Miao, Xiaoying Huang
doaj +1 more source
When accuracy rates and mean response times lead to false conclusions: A simulation study based on the diffusion model [PDF]
Tutorials in Quantitative Methods for Psychology, 2020 The diffusion model belongs to the class of sequential sampling models. Based on information about RT distributions from binary tasks, the model allows the separation of distinct processes underlying decision-making. With the present simulation study, we
Lerche, Veronika, Voss, Andreas
doaj +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Frontiers in Neuroscience, 2014 As the strength of a stimulus increases, the proportions of correct binary responses increases, which define the psychometric function. Simultaneously, mean reaction times (RT) decrease, which collectively define the chronometric function. However, RTs
James V Stone
doaj +1 more source
Structural centrality of networks can improve the diffusion-based recommendation algorithm
Frontiers in Physics, 2022 The recommendation system has become an indispensable information technology in the real world. The recommendation system based on the diffusion model has been widely used because of its simplicity, scalability, interpretability, and many other ...
Yixiu Kong +3 more
doaj +1 more source
Consistency Problems for Jump-Diffusion Models
, 2005 In this paper consistency problems for multi-factor jump-diffusion models, where the jump parts follow multivariate point processes are examined. First the gap between jump-diffusion models and generalized Heath-Jarrow-Morton (HJM) models is bridged.
Brito RD +6 more
core +2 more sources