Results 71 to 80 of about 2,118,011 (294)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Ground-Truth-Free 3D Seismic Denoising Based on Diffusion Models: Achieving Effective Constraints Through Embedded Self-Supervised Noise Modeling

Remote Sensing
Three-dimensional (3D) seismic data, essential for revealing subsurface structures and exploring oil and gas resources, are often contaminated by noise with an unknown prior distribution.
Zhonghan Zhang, Guihe Qin, Yanhua Liang, Minghui Sun, Yingqing Wang, Jiaru Song   +5 more
doaj   +1 more source

Paper-Based Assessment of the Effects of Aging on Response Time: A Diffusion Model Analysis

Journal of Intelligence, 2017
The effects of aging on response time were examined in a paper-based lexical-decision experiment with younger (age 18–36) and older (age 64–75) adults, applying Ratcliff’s diffusion model. Using digital pens allowed the paper-based assessment of response
Judith Dirk, Gesa Katharina Kratzsch, John P. Prindle, Ulf Kröhne, Frank Goldhammer, Florian Schmiedek   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

High‐Asymmetry Metasurface: A New Solution for Terahertz Resonance via Active Learning‐Augmented Diffusion Model

Advanced Science
Terahertz (THz) metamaterials with high‐figure‐of‐merit (high‐FoM) performance resonance are essential for advancing sensors, detectors, and imagers. Conventional designs focus on symmetric or low‐asymmetry geometric structures, leaving high‐asymmetry ...
Qiqi Dai, Yinpeng Wang, Cheng Xu, Dongxiao Li, Prakash Pitchappa, Thomas Caiwei Tan, Ranjan Singh, Chengkuo Lee   +7 more
doaj   +1 more source

Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel

Pharmaceutics, 2016
Effective topical therapy of cutaneous fungal diseases requires the delivery of the active agent to the target site in adequate concentrations to produce a pharmacological effect and inhibit the growth of the pathogen.
Mahima Manian, Kumpal Madrasi, Ayyappa Chaturvedula, Ajay K. Banga   +3 more
doaj   +1 more source

Comparing Eight Parameter Estimation Methods for the Ratcliff Diffusion Model Using Free Software

Frontiers in Psychology, 2020
The Ratcliff Diffusion Model has become an important and widely used tool for the evaluation of psychological experiments. Concurrently, numerous programs and routines have appeared to estimate the model's parameters.
Rainer W. Alexandrowicz, Bartosz Gula
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Diff-Tree: A Diffusion Model for Diversified Tree Point Cloud Generation with High Realism

Remote Sensing
Three-dimensional (3D) virtual trees play a vital role in modern forestry research, enabling the visualization of forest structures and supporting diverse simulations, including radiation transfer, climate change impacts, and dynamic forest management ...
Haifeng Xu, Yongjian Huai, Xiaoying Nie, Qingkuo Meng, Xun Zhao, Xuanda Pei, Hao Lu   +6 more
doaj   +1 more source

Effects of nongaussian diffusion on "isotropic diffusion measurements'': an ex-vivo microimaging and simulation study

, 2019
Designing novel diffusion-weighted pulse sequences to probe tissue microstructure beyond the conventional Stejskal-Tanner family is currently of broad interest.
Ianuş, Andrada, Jespersen, Sune Nørhøj, Olesen, Jonas Lynge, Shemesh, Noam   +3 more
core   +1 more source