Results 151 to 160 of about 836 (184)
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Organic Letters
Axially chiral allenes are valuable motifs in natural products and chiral ligands in asymmetric catalysis, yet methods to access enantioenriched difluoromethylated analogues remain undeveloped. Here we report the efficient copper-catalyzed SN2'-type substitution of propargylic alcohol derivatives with Zn(CF2H)2(DMPU)2, to deliver enantioenriched ...
Su Chen +5 more
openaire +2 more sources
Axially chiral allenes are valuable motifs in natural products and chiral ligands in asymmetric catalysis, yet methods to access enantioenriched difluoromethylated analogues remain undeveloped. Here we report the efficient copper-catalyzed SN2'-type substitution of propargylic alcohol derivatives with Zn(CF2H)2(DMPU)2, to deliver enantioenriched ...
Su Chen +5 more
openaire +2 more sources
Journal of Fluorine Chemistry, 2007
We have successfully achieved nucleophilic (phenylsulfinyl)difluoromethylation of both enolizable and non-enolizable aldehydes and ketones by using difluoromethyl phenyl sulfone (1) as the fluoroalkylating agent. Although the chemical yields of the reactions are good to excellent, the observed diastereoselectivity is poor (dr = 1:1.04-2.03).
Lingui Zhu +7 more
openaire +1 more source
We have successfully achieved nucleophilic (phenylsulfinyl)difluoromethylation of both enolizable and non-enolizable aldehydes and ketones by using difluoromethyl phenyl sulfone (1) as the fluoroalkylating agent. Although the chemical yields of the reactions are good to excellent, the observed diastereoselectivity is poor (dr = 1:1.04-2.03).
Lingui Zhu +7 more
openaire +1 more source
Preparation of (Fluoromethyl)‐ and (Difluoromethyl)imidazoles.
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Bohumil Dolensky, Kenneth L. Kirk
openaire +1 more source
Generating Diversity in Difluoromethyl Ketone Derivatives
Organic Letters, 2001[reaction: see text]. Two consecutive palladium-catalyzed coupling reactions from a readily available difluoroenol stannane set the stage for the synthesis of a range of difluoro- and halodifluoromethyl ketones upon a variable aryl template.
DeBoos, Gareth A +2 more
openaire +4 more sources
Silver-Enabled General Radical Difluoromethylation Reaction with TMSCF2H
Angewandte Chemie - International Edition, 2021Lingling Chu, Feng-Ling Qing, Fang Wang
exaly
A General Protocol for C−H Difluoromethylation of Carbon Acids with TMSCF2Br
Angewandte Chemie - International Edition, 2019Chuanfa Ni, Jinbo Hu, Ziyue Zhu
exaly