Results 141 to 150 of about 836 (184)

Copper-Catalyzed Decarboxylative Difluoromethylation

Journal of the American Chemical Society, 2019
We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can convert a diverse array of acid-containing complex molecules to the alkyl-CF2H products ...
Xiaojun Zeng, Wenhao Yan, Samson B. Zacate, Tzu-Hsuan Chao, Xiaodong Sun, Zhi Cao, Kate G. E. Bradford, Matthew Paeth, Sam B. Tyndall, Kundi Yang, Tung-Chun Kuo, Mu-Jeng Cheng, Wei Liu   +12 more
openaire   +2 more sources

A Difluoromethylation Reagent: Access to Difluoromethyl Arenes through Palladium Catalysis

Organic Letters
A new radical difluoromethylation was developed by using inexpensive and readily available difluoroacetic anhydride and N-phenyl-4-methylbenzenesulfonamide for the first time. The reaction of arylboronic acids with the new difluoromethylation reagent, N-phenyl-N-tosyldifluoroacetamide, proceeded smoothly in the presence of palladium catalyst to provide
Xia Chen, Yining Liu, Sheng Zhang, Yang Li, Xiao-Yu Zhou, Xiaoqiang Yu, Xiujuan Feng, Yoshinori Yamamoto, Ming Bao   +8 more
openaire   +2 more sources

Difluoromethane as a precursor to difluoromethyl borates

Chemical Communications, 2019
Difluoromethane (CF 2 H 2 ) is an ecologically-friendly refrigerant which holds promise as a source of CF 2 H − .
Jacob B. Geri, Ellen Y. Aguilera, Nathaniel K. Szymczak   +2 more
openaire   +2 more sources

Photocatalytic Hydro Tri/Difluoromethylation of Alkenes with Bench Stable Tri/Difluoromethylating Reagents

Organic Letters, 2023
Herein, we demonstrate the synthesis and characterization of bench stable tri/difluoromethylating reagents and their potential applications in redox neutral hydro tri/difluoromethylation of alkenes enabled by visible light. The new tri/difluoromethylating reagents are obtained on a gram-scale through simply cyclocondensation of commercially available ...
Girish Suresh Yedase, Munaifa Arif, Rositha Kuniyil, Veera Reddy Yatham   +3 more
openaire   +2 more sources

Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives

Organic Letters
Electron-rich, electron-deficient, and non-activated alkenes can be rapidly functionalized by in situ-generated difluoromethyl nitrile oxide. The (3+2) cycloaddition proceeds at room temperature, has broad functional group tolerance, and can be used for the late-stage modification of bioactive molecules (finasteride and carbamazepine).
Bohdan A. Chalyk, Oleksandr Zginnyk, Andrii V. Khutorianskyi, Pavel K. Mykhailiuk   +3 more
openaire   +2 more sources

Copper‐Catalyzed Deaminative Difluoromethylation

Angewandte Chemie International Edition, 2020
AbstractThe difluoromethyl group (CF2H) is considered to be a lipophilic and metabolically stable bioisostere of an amino (NH2) group. Therefore, methods that can rapidly convert an NH2 group into a CF2H group would be of great value to medicinal chemistry. We report herein an efficient Cu‐catalyzed approach for the conversion of alkyl pyridinium salts,
Xiaojun Zeng, Wenhao Yan, Samson B. Zacate, Aijie Cai, Yufei Wang, Dongqi Yang, Kundi Yang, Wei Liu   +7 more
openaire   +2 more sources

Synthesis of Difluoromethyl Thioethers from Difluoromethyl Trimethylsilane and Organothiocyanates Generated In Situ

Angewandte Chemie International Edition, 2015
AbstractA copper‐CF2H complex generated in situ from copper thiocyanate and TMSCF2H smoothly converts organothiocyanates into valuable difluoromethyl thioethers. This reaction step can be combined with several thiocyanation methods to one‐pot protocols, allowing late‐stage difluoromethylthiolations of widely available alkyl halides and arenediazonium ...
Bilguun, Bayarmagnai, Christian, Matheis, Kévin, Jouvin, Lukas J, Goossen   +3 more
openaire   +2 more sources

Difluoromethylation of Terminal Alkynes by Fluoroform

Organic Letters, 2015
The difluoromethylation of terminal alkynes through the use of fluoroform as a source of difluorocarbene is described. The choice of solvents and bases was found to be crucial for the transformation. A series of terminal alkynes 1 were nicely converted into the corresponding difluoromethyl alkynes 2 using potassium tert-butoxide in n-decane in moderate
Satoshi, Okusu, Etsuko, Tokunaga, Norio, Shibata   +2 more
openaire   +2 more sources

Visible-Light-Driven Difluoromethylation of Isocyanides with S-(Difluoromethyl)diarylsulfonium Salt: Access to a Wide Variety of Difluoromethylated Phenanthridines and Isoquinolines

The Journal of Organic Chemistry, 2020
A highly efficient approach of visible-light-driven radical difluoromethylation of isocyanides to access a wide variety of difluoromethylated phenanthridines and isoquinolines is herein described. Electrophilic S-(difluoromethyl)diarylsulfonium salt proved to be a good difluoromethyl radical precursor under photoredox catalysis.
Wen-Bing Qin, Wei Xiong, Xin Li, Jia-Yi Chen, Li-Ting Lin, Henry N. C. Wong, Guo-Kai Liu   +6 more
openaire   +2 more sources

Nucleophilic difluoromethylation of CN bonds in heterocycles with difluoromethyl silane reagents

Tetrahedron, 2012
An efficient and straightforward nucleophilic difluoromethylation of C=N bonds in heterocycles under the activation of alkylating agents has been developed. Cyclic iminium salts derived from dihydroisoquinolines, quinolines, and pyridines were successfully difluoromethylated with sulfur-based fluoroalkyl silanes affording a series of new ...
Weizhou Huang, Chuanfa Ni, Yanchuan Zhao, Wei Zhang, Alexander D. Dilman, Jinbo Hu   +5 more
openaire   +1 more source