Results 131 to 140 of about 836 (184)
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Synthesis of Difluoromethyl-Substituted Quinazolines through Selective Difluoromethylation
Synthesis, 2021AbstractA highly selective difluoromethylation of quinazolines has been achieved by using commercially available ethyl bromodifluoroacetate as difluorocarbene precursor, providing the corresponding difluoromethyl substituted quinazoline derivatives with up to 83% yield.
Yiyuan Peng +4 more
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(Difluoromethyl)trimethylsilane (TMSCHF2): A Useful Difluoromethylating Nucleophilic Source
Australian Journal of Chemistry, 2021Significant advancements have been achieved due to the excellent versatility of the commercially available (difluoromethyl)trimethylsilane (TMSCHF2) as a competent donor of the CHF2 group under nucleophilic regime.[2] It is a commercially or easily accessible liquid documenting excellent experimental manipulability due to its relatively high boiling ...
Miele M., Pace V.
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Difluoromethylation of Sulfonamides.
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
K. I. Petko +2 more
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Radical Difluoromethylation of Thiols with (Difluoromethyl)triphenylphosphonium Bromide
Organic Letters, 2017A method for facile difluoromethylation of various thiols using (difluoromethyl)triphenylphosphonium bromide under mild reaction conditions is presented. The transformation proceeds in the absence of any transition metal using a bench-stable and readily accessible phosphonium salt.
Niklas B. Heine, Armido Studer
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Direct Difluoromethylation of Alcohols with an Electrophilic Difluoromethylated Sulfonium Ylide
Angewandte Chemie International Edition, 2016AbstractA general method for the formation of alkyl difluoromethylethers under mild reaction conditions and with good functional‐group tolerance was developed. The development of the method was based on the invention of a stable, electrophilic, difluoromethylating reagent, difluoromethyl‐(4‐nitrophenyl)‐bis(carbomethoxy) methylide sulfonium ylide ...
Jiansheng, Zhu, Yafei, Liu, Qilong, Shen
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Difluoromethylation of 5-Sulfanyltetrazoles
Russian Journal of Organic Chemistry, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
K. I. Petko, L. M. Yagupol'skii
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Copper-Catalyzed Difluoromethylation of Aryl Iodides with (Difluoromethyl)zinc Reagent
Organic Letters, 2016The combination of difluoroiodomethane and zinc dust or diethylzinc can readily lead to (difluoromethyl)zinc reagents. Therefore, the first copper-catalyzed difluoromethylation of aryl iodides with the zinc reagents is accomplished to afford the difluoromethylated arenes.
Hiroki, Serizawa +3 more
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Chemical Communications, 2020
A one-pot difluoromethylthiolation of alkyl electrophiles with thiourea and diethyl bromodifluoromethylphosphonate is described. By changing the “H” source to most commonly used “D” source CD 3 OD and D 2 O, this strategy enables efficient synthesis of ...
Tianqi Ding, Lvqi Jiang, Wenbin Yi
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A one-pot difluoromethylthiolation of alkyl electrophiles with thiourea and diethyl bromodifluoromethylphosphonate is described. By changing the “H” source to most commonly used “D” source CD 3 OD and D 2 O, this strategy enables efficient synthesis of ...
Tianqi Ding, Lvqi Jiang, Wenbin Yi
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Iron-Catalyzed Difluoromethylation of Arylzincs with Difluoromethyl 2-Pyridyl Sulfone
Journal of the American Chemical Society, 2018We report the first iron-catalyzed difluoromethylation of arylzincs with difluoromethyl 2-pyridyl sulfone via selective C-S bond cleavage. This method employs the readily available, bench-stable fluoroalkyl sulfone reagent and inexpensive iron catalyst, allowing facile access to structurally diverse difluoromethylated arenes at low temperatures.
Wenjun Miao +5 more
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Selective difluoromethylation and monofluoromethylation reactions
Chemical Communications, 2009The selective introduction of fluorine atom(s) and fluorinated moieties into organic molecules has become an important and fast-growing research field, since fluorine atoms play crucial roles in life science and materials science-related applications. Similar to the trifluoromethyl group, both difluoromethyl and monofluoromethyl groups can often bring ...
Jinbo, Hu, Wei, Zhang, Fei, Wang
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