Results 111 to 120 of about 375 (147)
Some of the next articles are maybe not open access.
Organic Letters
Axially chiral allenes are valuable motifs in natural products and chiral ligands in asymmetric catalysis, yet methods to access enantioenriched difluoromethylated analogues remain undeveloped. Here we report the efficient copper-catalyzed SN2'-type substitution of propargylic alcohol derivatives with Zn(CF2H)2(DMPU)2, to deliver enantioenriched ...
Su Chen +5 more
openaire +2 more sources
Axially chiral allenes are valuable motifs in natural products and chiral ligands in asymmetric catalysis, yet methods to access enantioenriched difluoromethylated analogues remain undeveloped. Here we report the efficient copper-catalyzed SN2'-type substitution of propargylic alcohol derivatives with Zn(CF2H)2(DMPU)2, to deliver enantioenriched ...
Su Chen +5 more
openaire +2 more sources
Difluoromethane as a precursor to difluoromethyl borates
Chemical Communications, 2019Difluoromethane (CF 2 H 2 ) is an ecologically-friendly refrigerant which holds promise as a source of CF 2 H − .
Jacob B. Geri +2 more
openaire +2 more sources
Nucleophilic difluoromethylation of CN bonds in heterocycles with difluoromethyl silane reagents
Tetrahedron, 2012An efficient and straightforward nucleophilic difluoromethylation of C=N bonds in heterocycles under the activation of alkylating agents has been developed. Cyclic iminium salts derived from dihydroisoquinolines, quinolines, and pyridines were successfully difluoromethylated with sulfur-based fluoroalkyl silanes affording a series of new ...
Weizhou Huang +5 more
openaire +1 more source
Journal of Fluorine Chemistry, 2007
We have successfully achieved nucleophilic (phenylsulfinyl)difluoromethylation of both enolizable and non-enolizable aldehydes and ketones by using difluoromethyl phenyl sulfone (1) as the fluoroalkylating agent. Although the chemical yields of the reactions are good to excellent, the observed diastereoselectivity is poor (dr = 1:1.04-2.03).
Lingui Zhu +7 more
openaire +1 more source
We have successfully achieved nucleophilic (phenylsulfinyl)difluoromethylation of both enolizable and non-enolizable aldehydes and ketones by using difluoromethyl phenyl sulfone (1) as the fluoroalkylating agent. Although the chemical yields of the reactions are good to excellent, the observed diastereoselectivity is poor (dr = 1:1.04-2.03).
Lingui Zhu +7 more
openaire +1 more source
Preparation of (Fluoromethyl)‐ and (Difluoromethyl)imidazoles.
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Bohumil Dolensky, Kenneth L. Kirk
openaire +1 more source
Organic & Biomolecular Chemistry, 2017
A photoredox-catalyzed direct difluoromethylation of alkynoates has been developed.
Mei Zhu +4 more
openaire +2 more sources
A photoredox-catalyzed direct difluoromethylation of alkynoates has been developed.
Mei Zhu +4 more
openaire +2 more sources
Generating Diversity in Difluoromethyl Ketone Derivatives
Organic Letters, 2001[reaction: see text]. Two consecutive palladium-catalyzed coupling reactions from a readily available difluoroenol stannane set the stage for the synthesis of a range of difluoro- and halodifluoromethyl ketones upon a variable aryl template.
DeBoos, Gareth A +2 more
openaire +4 more sources
Silver‐Enabled General Radical Difluoromethylation Reaction with TMSCF2H
Angewandte Chemie - International Edition, 2021Lingling Chu +2 more
exaly