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Recent Advances in Visible Light-Induced C-H Functionalization of Imidazo[1,2-a]pyridines. [PDF]
MoleculesGao J, Fu X, Yang K, Liu Z.
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Copper‐Catalyzed Deaminative Difluoromethylation
Angewandte Chemie - International Edition, 2020AbstractThe difluoromethyl group (CF2H) is considered to be a lipophilic and metabolically stable bioisostere of an amino (NH2) group. Therefore, methods that can rapidly convert an NH2 group into a CF2H group would be of great value to medicinal chemistry. We report herein an efficient Cu‐catalyzed approach for the conversion of alkyl pyridinium salts,
Wei Liu, Aijie Cai, Xiaojun Zeng
exaly +3 more sources
Difluoromethylation Reactions of Organic Compounds
Chemistry - A European Journal, 2017AbstractThe relevance of the ‐CF2H moiety has attracted considerable attention from organic synthetic and medicinal chemistry communities, because this group can act as a more lipophilic isostere of the carbinol, thiol, hydroxamic acid, or amide groups.
Sebastian Barata Vallejo +2 more
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(Difluoromethyl)trimethylsilane (TMSCHF2): A Useful Difluoromethylating Nucleophilic Source
Australian Journal of Chemistry, 2021Significant advancements have been achieved due to the excellent versatility of the commercially available (difluoromethyl)trimethylsilane (TMSCHF2) as a competent donor of the CHF2 group under nucleophilic regime.[2] It is a commercially or easily accessible liquid documenting excellent experimental manipulability due to its relatively high boiling ...
Miele M., Pace V.
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Synthesis of Difluoromethyl-Substituted Quinazolines through Selective Difluoromethylation
Synthesis, 2021AbstractA highly selective difluoromethylation of quinazolines has been achieved by using commercially available ethyl bromodifluoroacetate as difluorocarbene precursor, providing the corresponding difluoromethyl substituted quinazoline derivatives with up to 83% yield.
Yiyuan Peng +4 more
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Difluoromethylation of Sulfonamides.
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
K. I. Petko +2 more
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Radical Difluoromethylation of Thiols with (Difluoromethyl)triphenylphosphonium Bromide
Organic Letters, 2017A method for facile difluoromethylation of various thiols using (difluoromethyl)triphenylphosphonium bromide under mild reaction conditions is presented. The transformation proceeds in the absence of any transition metal using a bench-stable and readily accessible phosphonium salt.
Niklas B. Heine, Armido Studer
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Direct Difluoromethylation of Alcohols with an Electrophilic Difluoromethylated Sulfonium Ylide
Angewandte Chemie International Edition, 2016AbstractA general method for the formation of alkyl difluoromethylethers under mild reaction conditions and with good functional‐group tolerance was developed. The development of the method was based on the invention of a stable, electrophilic, difluoromethylating reagent, difluoromethyl‐(4‐nitrophenyl)‐bis(carbomethoxy) methylide sulfonium ylide ...
Jiansheng, Zhu, Yafei, Liu, Qilong, Shen
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Difluoromethylation of 5-Sulfanyltetrazoles
Russian Journal of Organic Chemistry, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
K. I. Petko, L. M. Yagupol'skii
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Copper-Catalyzed Difluoromethylation of Aryl Iodides with (Difluoromethyl)zinc Reagent
Organic Letters, 2016The combination of difluoroiodomethane and zinc dust or diethylzinc can readily lead to (difluoromethyl)zinc reagents. Therefore, the first copper-catalyzed difluoromethylation of aryl iodides with the zinc reagents is accomplished to afford the difluoromethylated arenes.
Hiroki, Serizawa +3 more
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